D0632
DL-Dithiothreitol
≥98% (HPLC), ≥99.0% (titration)
Synonym(s):
(±)-Dithiothreitol, rac-Dithiothreitol, Dithiothreitol, threo-1,4-Dimercapto-2,3-butanediol, Cleland’s reagent, DTT
About This Item
Recommended Products
Quality Level
assay
≥98% (HPLC)
≥99.0% (titration)
form
powder
reaction suitability
reagent type: reductant
color
white
mp
41-44 °C (lit.)
solubility
H2O: soluble 50 mg/mL, clear, colorless to very faintly yellow
application(s)
general analytical
storage temp.
2-8°C
SMILES string
O[C@H](CS)[C@H](O)CS
InChI
1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m1/s1
InChI key
VHJLVAABSRFDPM-QWWZWVQMSA-N
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Related Categories
General description
Application
- as one of the reactants in the reduction and alkylation of αs1-Casein, the major allergen of cow′s milk.
- as a component of medium for the demembranation and reactivation of spermatozoa.
- to maintain stability of the enzyme as thiol effectively protects the active sites of the biocatalyst.
- as a reducing agent to test the specificity of the reaction of N-Ethylmaleimide with sulfhydryl groups.
- in proteomics analysis as in-solution protein digestion for mass spectrometry
- as a buffer component for protein quantification, to prepare wash buffer, lysis buffer, sample buffer, and protein elution buffer
Biochem/physiol Actions
Features and Benefits
- High-quality DTT (HPLC≥98%), (titration≥99.0%)
- Suitable for electrophoresis, proteomics analysis
Other Notes
also commonly purchased with this product
comparable product
suggested gloves for splash protection
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Comparative analysis of different columns in resolving medium-sized fragments of monoclonal antibodies, after digestion using dithiothreitol (DTT) or IdeS (a protease), by Reversed-Phase Chromatography.
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