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A5882

Supelco

Antipyrine

analytical standard

Synonym(s):

2,3-Dimethyl-1-phenyl-3-pyrazolin-5-one, Phenazone

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About This Item

Empirical Formula (Hill Notation):
C11H12N2O
CAS Number:
60-80-0
Molecular Weight:
188.23
Beilstein/REAXYS Number:
157775
EC Number:
200-486-6
MDL number:
MFCD00003146
UNSPSC Code:
41116107
PubChem Substance ID:
24891029

grade

analytical standard

Quality Level

100

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

109-111 °C (lit.)

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

CN1N(C(=O)C=C1C)c2ccccc2

InChI

1S/C11H12N2O/c1-9-8-11(14)13(12(9)2)10-6-4-3-5-7-10/h3-8H,1-2H3

InChI key

VEQOALNAAJBPNY-UHFFFAOYSA-N

Gene Information

human ... PTGS1(5742)

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Antipyrine may be used as:
  • Pharmaceutical reference standard for the determination of the analyte in animal plasma and serum by various chromatography techniques.
  • Internal standard for the analysis of creatinine and uric acid in human plasma by micellar electrokinetic chromatography.
  • Reference standard to investigate the effect of diseases, pharmaceuticals, and environmental factors on hepatic oxidative metabolism activity in humans and animals in vivo, owing to its physicochemical, biochemical, and pharmacokinetic properties.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

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Nicotinamide ≥98.5% (HPLC)

Sigma-Aldrich

72345

Nicotinamide

Meglumine diatrizoate organic

Sigma-Aldrich

M5266

Meglumine diatrizoate

High-pressure liquid chromatographic analysis of antipyrine in small plasma samples
Shargel L, et al.
Journal of Pharmaceutical Sciences, 68(8), 1052-1054 (1979)
Rapid determination of drugs in biofluids by capillary electrophoresis Measurement of antipyrine in saliva for pharmacokinetic studies
Perrett D and Ross GA
Journal of Chromatography A, 700(1-2), 179-186 (1995)
Automated high-performance liquid chromatographic determination of antipyrine and its main metabolites in plasma, saliva and urine, including 4, 4?-dihydroxy-antipyrine
Teunissen MWE, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 278(3), 367-378 (1983)
Simultaneous determination of creatinine and uric acid in human plasma and urine by micellar electrokinetic chromatography
Miyake M, et al.
Journal of High Resolution Chromatography, 14(3), 181-185 (1991)
Antipyrine, indocyanine green, and lorazepam determined in plasma by high-pressure liquid chromatography.
Awni WM and Bakker LJ
Clinical Chemistry, 35(10), 2124-2126 (1989)
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