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A9797

Supelco

Ambroxol hydrochloride

analytical standard

Synonym(s):

2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine

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About This Item

Empirical Formula (Hill Notation):
C13H18Br2N2O · HCl
CAS Number:
23828-92-4
Molecular Weight:
414.56
EC Number:
245-899-2
MDL number:
MFCD00078932
UNSPSC Code:
41116107
PubChem Substance ID:
329771060
NACRES:
NA.24

grade

analytical standard

Quality Level

100

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

SMILES string

Cl.Nc1c(Br)cc(Br)cc1CN[C@@H]2CC[C@@H](O)CC2

InChI

1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H/t10-,11-;

InChI key

QNVKOSLOVOTXKF-PFWPSKEQSA-N

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General description

Ambroxol hydrochloride is a mucolytic expectorant and a metabolite of bromhexine. It is used in the treatment of respiratory disorders characterized by viscous or excessive mucus.

Application

Ambroxol hydrochloride standard may be used as a reference standard in the determination of ambroxol hydrochloride in pharmaceutical preparations using reversed-phase sequential injection chromatography (RP-SIC) and reversed-phase high performance liquid chromatography (RP-HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Metabolite of bromhexine.
A Nav1.8-preferring sodium channel blocker

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Concise Dictionary of Pharmacological Agents: Properties and Synonyms (2012)
Jauch, R., et al.
Arzneimittelforschung, 13, 474-474 (1963)
Wolfram Gaida et al.
Neuropharmacology, 49(8), 1220-1227 (2005-09-27)
Neuropathic pain affects many patients, and treatment today is far from being perfect. Nav1.8 Na(+) channels, which are expressed by small fibre sensory neurons, are promising targets for novel analgesics. Na(+) channel blockers used today, however, show only limited selectivity
Sequential injection chromatographic determination of ambroxol hydrochloride and doxycycline in pharmaceutical preparations.
Satinsky D, et al.
Talanta, 68(2), 214-218 (2005)
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Redox biology, 41, 101926-101926 (2021-03-23)
Chemosensitivity to cisplatin derivatives varies among individual patients with intractable malignancies including ovarian cancer, while how to unlock the resistance remain unknown. Ovarian cancer tissues were collected the debulking surgery in discovery- (n = 135) and validation- (n = 47) cohorts, to be analyzed
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