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BP460

Nicotinamide

British Pharmacopoeia (BP) Reference Standard

Synonym(s):

NAM, NIC, Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B3, Vitamin PP

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About This Item

Empirical Formula (Hill Notation):
C6H6N2O
CAS Number:
98-92-0
Molecular Weight:
122.12
Beilstein/REAXYS Number:
383619
MDL number:
MFCD00006395
UNSPSC Code:
12352200
NACRES:
NA.24

grade

pharmaceutical primary standard

agency

BP

API family

nicotinamide

form

solid

manufacturer/tradename

BP

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

128-131 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

SMILES string

NC(=O)c1cccnc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

InChI key

DFPAKSUCGFBDDF-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Nicotinamide, a member of the family of water-soluble B vitamins, is generally produced from nicotinic acid (vitamin B3). It is often present in food products. It has been reported to have been effective in the treatment of pellagra, psoriasis, schizophrenia, and type I diabetes. It is also shown to possess anti-inflammatory activity.

Application

Nicotinamide BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Vitamins B and C Injection
  • Nicorandil Tablets

    • Biochem/physiol Actions

    Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

    Packaging

    Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    Other Notes

    Sales restrictions may apply.

    pictograms

    Exclamation mark
    GHS07

    signalword

    Warning

    hcodes

    H319

    Hazard Classifications

    Eye Irrit. 2

    Storage Class

    11 - Combustible Solids

    wgk_germany

    WGK 1

    flash_point_f

    302.0 °F - closed cup

    flash_point_c

    150 °C - closed cup

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    Sigma-Aldrich

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    PHR1033

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    Nicotinamide (Vitamin B3) solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

    Supelco

    V-016

    Nicotinamide (Vitamin B3) solution

    Riboflavin sodium phosphate European Pharmacopoeia (EP) Reference Standard

    R0630000

    Riboflavin sodium phosphate

    Niacin United States Pharmacopeia (USP) Reference Standard

    USP

    1461003

    Niacin

    Nicotinamide
    European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
    European pharmacopoeia, 14(4), 3145-3146 (2017)
    Evaluation of analytical tools and multivariate methods for quantification of co-former crystals in ibuprofen-nicotinamide co-crystals
    Soares FLF and Carneiro RL
    Journal of Pharmaceutical and Biomedical Analysis, 89, 166-175 (2014)
    Development of a validated HPLC method for the determination of B-complex vitamins in pharmaceuticals and biological fluids after solid phase extraction
    Chatzimichalakis PF, et al.
    Journal of Separation Science, 27(14), 1181-1188 (2004)
    Simultaneous determination and classification of riboflavin, thiamine, nicotinamide and pyridoxine in pharmaceutical formulations, by UV-visible spectrophotometry and multivariate analysis
    Lopez-de-Alba LP, et al.
    Journal of the Brazilian Chemical Society, 17(4), 715-722 (2006)
    Youdan Shi et al.
    International immunopharmacology, 14(4), 530-537 (2012-10-13)
    Nicotinamide (NAM), the amide form of vitamin B3, is involved in a wide range of biological processes. Recent evidence revealed the anti-inflammatory and anti-oxidant properties of NAM and suggests it may be used as a novel strategy in the prevention

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