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C0400000

Calcium pantothenate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

D-Pantothenic acid hemicalcium salt, (R)-(+)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine hemicalcium salt, Calcium D-pantothenate, Vitamin B5

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About This Item

Linear Formula:
HOCH2C(CH3)2CH(OH)CONHCH2CH2CO2 ·1/2Ca
CAS Number:
137-08-6
Molecular Weight:
238.27
Beilstein/REAXYS Number:
3769272
MDL number:
MFCD00002766
UNSPSC Code:
41116107
PubChem Substance ID:
329774782
NACRES:
NA.24

biological source

synthetic

grade

pharmaceutical primary standard

agency

EP

API family

calcium pantothenate

form

solid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)O[Ca]OC(=O)CCNC(=O)[C@H](O)C(C)(C)CO

InChI

1S/2C9H17NO5.Ca/c2*1-9(2,5-11)7(14)8(15)10-4-3-6(12)13;/h2*7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13);/q;;+2/p-2/t2*7-;/m00./s1

InChI key

FAPWYRCQGJNNSJ-UBKPKTQASA-L

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Calcium pantothenate, the calcium salt of pantothenic acid, is a coenzyme A component that plays an important role in the metabolism of proteins, fats and carbohydrates. It is employed in vitamin supplements for the treatment of acne, osteoarthritis, rheumatoid arthritis, etc.

Application

Calcium pantothenate may be used as an EP reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography and spectrophotometric techniques.
Precursor in the biosynthesis of coenzyme A.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Physical properties

Due to the unstable, hygroscopic nature of the free acid, the calcium salt is employed.

Other Notes

Sales restrictions may apply.

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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HPLC determination of calcium pantothenate and two preservatives in topical cream
Havlikova L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 41(2), 671-675 (2006)
Calcium pantothenate
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 3, 6881-6882 (2019)
A reverse phase HPLC assay for the determination of calcium pantothenate utilizing column switching
Franks TJ and Stodola JD
Journal of Liquid Chromatography, 7(4), 823-837 (1984)
Vademecum for Vitamin Formulations (2001)
Solvent extraction and anion exchange chromatography for the spectrophotometric determination of calcium pantothenate in pharmaceutical products
Panalaks T and Campbell JA
Analytical Chemistry, 34(1), 64-66 (1962)
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