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C2180000

Cinnarizine

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

1-trans-Cinnamyl-4-diphenylmethylpiperazine

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About This Item

Empirical Formula (Hill Notation):
C26H28N2
CAS Number:
298-57-7
Molecular Weight:
368.51
MDL number:
MFCD00056037
UNSPSC Code:
41116107
PubChem Substance ID:
329774975
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

cinnarizine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

C1CN(CCN1C\C=C\c2ccccc2)C(c3ccccc3)c4ccccc4

InChI

1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/b13-10+

InChI key

DERZBLKQOCDDDZ-JLHYYAGUSA-N

Gene Information

human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779) , HRH1(3269)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Cinnarizine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Anne T Larsen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(1-2), 339-350 (2012-11-28)
The in vivo performance of self-nanoemulsifying drug delivery systems (SNEDDSs) with different in vitro physicochemical properties were determined with the purpose of elucidating the parameters determining the in vivo performance of SNEDDSs. The in vitro characterisation included the use of
P Y Cezarino et al.
Climacteric : the journal of the International Menopause Society, 14(4), 492-496 (2011-03-24)
To evaluate the effectiveness and safety of cinnarizine in the treatment of menopausal symptoms. A total of 100 climacteric and symptomatic women participated in a double-blind, placebo-controlled study. They were divided into two groups of the same size: Gcin, intake
Mohamed A Alhnan et al.
International journal of pharmaceutics, 416(1), 55-60 (2011-06-18)
Poorly water soluble basic drugs are very sensitive to pH changes and following dissolution in the acidic stomach environment tend to precipitate upon gastric emptying, which leads to compromised or erratic oral bioavailability. In this work, we show that the
Amnon Gil et al.
Clinical neuropharmacology, 35(1), 37-39 (2011-12-06)
The objective of the study was to compare the efficacy of transdermal scopolamine and cinnarizine in the prevention of seasickness and their adverse reactions. Seventy-six naval crew members participated in a double-blind, randomized, crossover study. On 2 voyages, they were
Tri-Hung Nguyen et al.
Journal of controlled release : official journal of the Controlled Release Society, 153(2), 180-186 (2011-04-19)
This study is the first to demonstrate the ability of nanostructured liquid crystal particles to sustain the absorption of a poorly water soluble drug after oral administration. Cubic (V(2)) liquid crystalline nanostructured particles (cubosomes) formed from phytantriol (PHY) were shown
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