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E0900000

Ergocalciferol

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Calciferol, Ercalciol, Ergosterol irradiated, Irradiated ergosterol, Vitamin D2

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About This Item

Empirical Formula (Hill Notation):
C28H44O
CAS Number:
50-14-6
Molecular Weight:
396.65
Beilstein/REAXYS Number:
1916682
MDL number:
MFCD00166988
UNSPSC Code:
41116107
PubChem Substance ID:
329798871
NACRES:
NA.24

biological source

synthetic

grade

pharmaceutical primary standard

agency

EP

API family

ergocalciferol

form

solid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

114-118 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

SMILES string

CC(C)[C@@H](C)/C=C/[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C

InChI

1S/C28H44O/c1-19(2)20(3)9-10-22(5)26-15-16-27-23(8-7-17-28(26,27)6)12-13-24-18-25(29)14-11-21(24)4/h9-10,12-13,19-20,22,25-27,29H,4,7-8,11,14-18H2,1-3,5-6H3/b10-9+,23-12+,24-13-/t20-,22+,25-,26+,27-,28+/m0/s1

InChI key

MECHNRXZTMCUDQ-RKHKHRCZSA-N

Gene Information

human ... VDR(7421)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Ergocalciferol is a form of vitamin D, synthesized by some plants in the presence of UVB light. It can be obtained from diet intake or supplements.

Application

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - STOT RE 1 Oral

Storage Class

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Cholecalciferol (D3)

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Sigma-Aldrich

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Cholecalciferol

Nutrition in the Prevention and Treatment of Disease (2008)
Simultaneous determination of cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2) in foods by selected reaction monitoring
Dimartino G
Journal of AOAC (Association of Official Analytical Chemists) International, 92(2), 511-517 (2002)
R Jorde et al.
European journal of endocrinology, 152(1), 39-45 (2005-03-15)
Smoking is associated with reduced bone density and calcium absorption, and reduced serum levels of vitamin D. A compensatory increase in serum parathyroid hormone (PTH) would therefore be expected as a result of an altered calcium balance. However, reports on
H A Bischoff-Ferrari et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 19(2), 265-269 (2004-02-19)
Intracellular 1,25-dihydroxyvitamin D receptor (VDR) is expressed in human skeletal muscle tissue. However, it is unknown whether VDR expression in vivo is related to age or vitamin D status, or whether VDR expression differs between skeletal muscle groups. We investigated
B L Salle et al.
The American journal of clinical nutrition, 71(5 Suppl), 1317S-1324S (2000-05-09)
During pregnancy, maternal serum concentrations of 25-hydroxyvitamin D, the circulating form of vitamin D, correlate with dietary vitamin D intake. Maternal serum concentrations of 1,25-dihydroxyvitamin D, the hormonal circulating and active form of vitamin D, are elevated during pregnancy; 1,25-dihydroxyvitamin
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Protocols

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AOAC Method 2011.11: UHPLC/MS/MS Analysis of Vitamin D2 and Vitamin D3 on Titan™ C18

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Separation of Retinyl acetate, analytical standard; δ-Tocopherol, analytical standard; Ergocalciferol (D2), analytical standard; Cholecalciferol (D3), analytical standard; (±)-α-Tocopherol, analytical standard; Vitamin E acetate, analytical standard; Phylloquinone (K1), analytical standard; Retinol palmitate, analytical standard.

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