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F7878

Supelco

Folinic acid calcium salt hydrate

analytical standard

Synonym(s):

5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt, 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt, 5-HCO-H4PteGlu, Calcium folinate, Citrovorum factor calcium salt, Leucovorin calcium salt

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About This Item

Empirical Formula (Hill Notation):
C20H21CaN7O7 · xH2O
CAS Number:
1492-18-8
Molecular Weight:
511.50 (anhydrous basis)
Beilstein/REAXYS Number:
5723924
UNSPSC Code:
41116107
PubChem Substance ID:
24894951
NACRES:
NA.24

biological source

synthetic (organic)

Quality Level

100

grade

analytical standard

assay

≥90.0%

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

yellow to orange

mp

240-250 °C

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

[Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13

InChI

1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1

InChI key

KVUAALJSMIVURS-ZEDZUCNESA-L

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General description

Folinic acid calcium salt hydrate is a drug, widely used for the treatment of cancer, since it can reduce toxic side effects and helps to improve drug accumulation in tumor tissues.

Application

Folinic acid calcium salt hydrate has been used as a test compound to study its effects on microglia involved in neuro-inflammation using enzyme-linked immunosorbent assay (ELISA) technique.
Folinic acid calcium salt hydrate has been used as a test compound to study its effects on microglia involved in neuro-inflammation using enzyme-linked immunosorbent assay (ELISA) technique. Folinic acid calcium salt hydrate may be used as an analytical reagent for the quantification of methotrexate its metabolites in biological samples using turbulent flow chromatography with tandem mass spectrometry.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Calcium folinate-(glutamyl-13C5) 99 atom % 13C, 97% (CP)

Sigma-Aldrich

665991

Calcium folinate-(glutamyl-13C5)

Folic acid-(glutamic acid-13C5) ≥99 atom % 13C, ≥95% (CP)

Sigma-Aldrich

803049

Folic acid-(glutamic acid-13C5)

Folic acid ≥97%

Sigma-Aldrich

F7876

Folic acid

The combination of vitamins and omega-3 fatty acids has an enhanced anti-inflammatory effect on microglia
Kurtys E, et al.
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