Skip to Content
MilliporeSigma
All Photos(6)

Documents

H3393

Sigma-Aldrich

Heparin sodium salt from porcine intestinal mucosa

Grade I-A, ≥180 USP units/mg

Synonym(s):

Sodium heparin

Sign Into View Organizational & Contract Pricing


About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352201
NACRES:
NA.21

biological source

Porcine intestinal mucosa

Quality Level

type

Grade I-A

form

powder

specific activity

≥180 USP units/mg

color

beige

useful pH range

5.0 - 7.5

solubility

H2O: 50 mg/mL, clear, colorless to faintly yellow

application(s)

clinical research
diagnostic assay manufacturing
life science and biopharma

storage temp.

room temp

Looking for similar products? Visit Product Comparison Guide

General description

Heparin is a glycosaminoglycan (GAG) belonging to the mucopolysaccharides family, known for its potent anticoagulant properties. This extensively sulfated polysaccharide consists of D-glucosamine and hexuronic acid linked via glycosidic linkages. It finds wide application in biochemical research and cell culture studies.

Application

Heparin sodium salt from porcine intestinal mucosa has been supplemented in the medium prepared for insemination of oocytes with spermatozoa. Heparin sodium salt from porcine intestinal mucosa has been used:
  • to check the effect of heparin on FGF21 (fibroblast growth factor 21) signaling.
  • in immunostaining of mice brain sections
  • to quantify white blood cells and red blood cells in Sparus aurata blood samples
  • in anticoagulation and severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) inhibition assay

Biochem/physiol Actions

Heparin is mainly responsible for the delay in the coagulation of blood. It enhances the antithrombin-mediated inactivation of proteases in the coagulation pathway.

Heparin is synthesized in mast cells and mediators such as histamine and is associated with allergy and inflammatory activity. Heparin shows therapeutic effects against venous thrombosis and pulmonary embolism, helps in preventing re-thrombosis post thrombolysis, and manages arterial thrombosis in patients who suffer from acute myocardial infarction. Heparin shows anti-inflammatory action in many inflammatory conditions such as burns, bronchial asthma, and ulcerative colitis.

Other Notes

For additional information on our range of Biochemicals, please complete this form.
Heparin solutions should not be autoclaved as additional crosslinking of the sugars may occur at high temperatures. It should not be frozen as well.
To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Recommended products

Heparin for diagnostic manufacturing is available as product number SRE0027

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 3

1 of 3

L Peter Sarin et al.
Nucleic acids research, 37(4), 1182-1192 (2009-01-09)
The RNA-dependent RNA polymerase (RdRP) of double-stranded RNA (dsRNA) viruses performs both RNA replication and transcription. In order to initiate RNA polymerization, viral RdRPs must be able to interact with the incoming 3' terminus of the template and position it
Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects.
Xu J et al.
American Journal of Physiology. Endocrinology and Metabolism, 297, E1105-E1105 (2009)
Bovine immature oocytes acquire developmental competence during meiotic arrest in vitro.
Hashimoto S et al.
Biology of Reproduction, 66, 1696-1696 (2002)
Sheikh Fayaz Ahmad et al.
Molecular neurobiology, 54(6), 4390-4400 (2016-06-28)
Autism is a neurodevelopmental disorder characterized by stereotypic repetitive behaviors, impaired social interactions, and communication deficits. Numerous immune system abnormalities have been described in individuals with autism including abnormalities in the ratio of Th1/Th2/Th17 cells; however, the expression of the
Benjamin Ziem et al.
Advanced healthcare materials, 5(22), 2922-2930 (2016-09-02)
Efficient inhibition of cell-pathogen interaction to prevent subsequent infection is an urgent but yet unsolved problem. In this study, the synthesis and functionalization of novel multivalent 2D carbon nanosystems as well as their antiviral efficacy in vitro are shown. For

Articles

There are five identified glycosaminoglycan chains (see Figure 1): Hyaluronan is not sulfated, but the other glycosaminoglycan chains contain sulfate substituents at various positions of the chain.

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service