I0775010
Isosorbide mononitrate
European Pharmacopoeia (EP) Reference Standard
Synonym(s):
1,4:3,6-Dianhydro-D-glucitol 5-nitrate
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About This Item
Empirical Formula (Hill Notation):
C6H9NO6
CAS Number:
Molecular Weight:
191.14
EC Number:
UNSPSC Code:
41116107
NACRES:
NA.24
Recommended Products
grade
pharmaceutical primary standard
API family
isosorbide
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
InChI
1S/C6H9NO6/c8-3-1-11-6-4(13-7(9)10)2-12-5(3)6/h3-6,8H,1-2H2/t3-,4+,5+,6+/m0/s1
InChI key
YWXYYJSYQOXTPL-SLPGGIOYSA-N
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Isosorbide mononitrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
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Description
Pricing
signalword
Danger
hcodes
Hazard Classifications
Flam. Sol. 1
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Tiantian Liu et al.
Chinese medicine, 15, 3-3 (2020-01-16)
The Chinese medicine Huoxue Wentong Formula (HXWTF) was used to treat thoracic obstruction and angina pectoris in clinic, which has not been investigated in myocardial ischemia-induced apoptosis and angiogenic function. Here we aimed to investigate the roles of HXWTF in
U Thadani et al.
The American journal of cardiology, 70(17), 67G-71G (1992-11-27)
The rapid development of tolerance has limited the applicability of oral and transdermal nitrates in the long-term management of patients with chronic stable angina pectoris. Recent well-controlled trials have demonstrated that asymmetrical, or eccentric, dosing of oral isosorbide mononitrate, in
A Prakash et al.
Drugs, 57(1), 93-99 (1999-02-10)
Elantan long (EL) is the only long-acting isosorbide mononitrate formulation based on a controlled membrane principle. 30% of the dose is available for immediate release and the remaining 70% is gradually released over time. After oral administration, isosorbide mononitrate EL
U W Abshagen
The American journal of cardiology, 70(17), 61G-66G (1992-11-27)
Pharmacokinetic studies show that isosorbide mononitrate is rapidly absorbed after oral administration, reaches peak concentrations within an hour, undergoes no significant first-pass metabolism, and is virtually 100% bioavailable. The half-life is approximately 5 hours, the volume of distribution is 0.62
Sayeed Hasan et al.
Journal of pharmaceutical sciences, 106(12), 3556-3563 (2017-08-27)
Extracellular polymeric substances in bacterial biofilms reduce the penetration of antimicrobials and give rise to extreme recalcitrance and treatment challenges for many persistent biofilms and associated infections. Nitric oxide (NO) is a promising alternative to conventional antimicrobials but is challenging
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