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M8506

Supelco

Methimazole

analytical standard

Synonym(s):

1-Methyl-2-mercaptoimidazole, MET, 1-Methyl-2-imidazolethiol, 2-Mercapto-1-methylimidazole

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About This Item

Empirical Formula (Hill Notation):
C4H6N2S
CAS Number:
60-56-0
Molecular Weight:
114.17
Beilstein/REAXYS Number:
108646
EC Number:
200-482-4
MDL number:
MFCD00179321
UNSPSC Code:
41116107
eCl@ss:
39161002
PubChem Substance ID:
329818061
NACRES:
NA.24

grade

analytical standard

Quality Level

200

assay

≥99%

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

144-147 °C (lit.)

application(s)

cleaning products
cosmetics
food and beverages
forensics and toxicology
personal care
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CN1C=CNC1=S

InChI

1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)

InChI key

PMRYVIKBURPHAH-UHFFFAOYSA-N

Gene Information

human ... TPO(7173)

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General description

Methimazole belongs to the chemical class of thioureylene compounds, used as an anti-thyroid drug in the management of hyperthyroidism.

Application

Beclomethasone dipropionate analytical standard can be used as follows:

  • Silver/graphene-modified carbon-paste electrode (AgGCPE) based electrochemical determination of methimazole
  • Development of a surface-enhanced Raman scattering (SERS) based method to estimate propylthiouracil and methimazole using sodium alginate-protected silver nanoparticles as SERS substrate
  • Detection of methimazole at ultra-trace limits using surface-enhanced Raman spectroscopy based on gold nanoparticles (AuNPs) substrate
  • Quantitative analysis of human blood samples for methimazole using high-performance liquid chromatography-tandem mass spectrometric (HPLC-MS/MS) method
  • Electrochemical determination of methimazole in pharmaceutical tablet and human blood serum samples by molecularly imprinted polymer (MIP)- pencil graphite electrode (PGE) based sensor

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Sens. 1

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number

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Determination of methimazole in urine with the iodine-azide detection system following its separation by reversed-phase high-performance liquid chromatography
Zakrzewski R
Journal of Chromatography. B, Biomedical Applications, 869(1-2), 67-74 (2008)
MMSPE-RP-HPLC method for the simultaneous determination of methimazole and selected metabolites in fish homogenates.
Hollosi L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 36(4), 921-924 (2004)
Francesco Isaia et al.
Journal of medicinal chemistry, 51(13), 4050-4053 (2008-06-06)
The antithyroid drug methimazole (MMI) reacts with molecular iodine to form, in a multistep process, 1-methylimidazole as final product. In this process, the charge transfer complex MMI-I 2 and the ionic disulfide [(C 4H 6N 2S-) 2] (2+) ( 1
Coralie Leblicq et al.
Pediatrics, 131(2), e616-e619 (2013-01-09)
A 15-year-old girl presented with chorea as a first sign of Graves' hyperthyroidism. Chorea abated with antithyroid drug treatment and reappeared when hyperthyroidism recurred but not when thyrotropin receptor antibodies increased after administration of (131)I. Therefore, chorea in this patient
F S Boretti et al.
Journal of veterinary internal medicine, 27(2), 377-381 (2013-02-13)
Transdermal methimazole is an acceptable alternative to oral treatment for hyperthyroid cats. There are, however, no studies evaluating the duration of T4 suppression after transdermal methimazole application. Such information would be valuable for therapeutic monitoring. To assess variation in serum
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