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PHR1026

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Ranitidine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

N, N Dimethyl-5-[2-(1-methylamine-2-nitrovinyl)-ethylthiomethyl]furfurylamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C13H22N4O3S · HCl
CAS Number:
66357-59-3
Molecular Weight:
350.86
EC Number:
266-333-0
MDL number:
MFCD00069339
UNSPSC Code:
41116107
PubChem Substance ID:
329823056
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to BP 471
traceable to Ph. Eur. R0150000
traceable to USP 1598405

API family

ranitidine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl[H].CN\C(NCCSCc1ccc(CN(C)C)o1)=C\[N+]([O-])=O

InChI

1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9-;

InChI key

GGWBHVILAJZWKJ-CHHCPSLASA-N

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General description

Ranitidine hydrochloride is a H2-receptor antagonist, widely used for the management of hypersecretory conditions and for the treatment of duodenal ulcer.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Ranitidine hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using titrimetry and visible spectrophotometry techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

H2 histamine receptor antagonist; anti-ulcer agent.
H2 histamine receptor antagonist; anti-ulcer agent.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA5630 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

1598405

Ranitidine hydrochloride, United States Pharmacopeia (USP) Reference Standard

1598507

Ranitidine Related Compound A, United States Pharmacopeia (USP) Reference Standard

1598700

Ranitidine Related Compound C, United States Pharmacopeia (USP) Reference Standard

1598609

Ranitidine Related Compound B, United States Pharmacopeia (USP) Reference Standard

1598450

Ranitidine Resolution Mixture, United States Pharmacopeia (USP) Reference Standard

Y0000416

Ranitidine impurity J, European Pharmacopoeia (EP) Reference Standard

R0150000

Ranitidine hydrochloride, European Pharmacopoeia (EP) Reference Standard

Y0001787

Ranitidine for impurity A identification, European Pharmacopoeia (EP) Reference Standard

PHR1774

Ranitidine Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1773

Ranitidine Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1775

Ranitidine Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material

BP471

Ranitidine hydrochloride, British Pharmacopoeia (BP) Reference Standard

PHR2180

Ranitidine Impurity I, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2181

Ranitidine Impurity J, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2179

Ranitidine Impurity H, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2182

Ranitidine Impurity K, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2175

Ranitidine Impurity D, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2177

Ranitidine Impurity F

PHR2178

Ranitidine Impurity G, Pharmaceutical Secondary Standard; Certified Reference Material

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD3507
LRAC3175
LRAB9973
LRAA5630
P500026

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Ranitidine Related Compound A United States Pharmacopeia (USP) Reference Standard

USP

1598507

Ranitidine Related Compound A

Spectrophotometric determination of ranitidine hydrochloride based on the reaction with p-dimethylaminobenzaldehyde
Narayana B, et al.
Eurasian Journal of Analytical Chemistry, 5(1), 63-72 (2010)
Shuang Zhang et al.
PloS one, 7(12), e51148-e51148 (2012-12-20)
Stress contributes to a variety of diseases and disorders such as depression and peptic ulcer. The present study aimed to investigate the correlation between stress ulcer and depression in pathogenesis and treatment by using chronic stress depression (CSD), chronic psychological
Julien Le Roux et al.
Environmental science & technology, 46(20), 11095-11103 (2012-09-13)
The kinetics of decomposition of the pharmaceutical ranitidine (a major precursor of NDMA) during chloramination was investigated and some decomposition byproducts were identified by using high performance liquid chromatography coupled with mass spectrometry (HPLC-MS). The reaction between monochloramine and ranitidine
Gaia Rocchitta et al.
Analytical chemistry, 84(16), 7072-7079 (2012-07-25)
Ethanol is one of the most widespread psychotropic agents in western society. While its psychoactive effects are mainly associated with GABAergic and glutamatergic systems, the positive reinforcing properties of ethanol are related to activation of mesolimbic dopaminergic pathways resulting in
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Epidemiologic and physiologic studies suggest an association between gastroesophageal reflux disease (GERD) and chronic cough. However, the benefit of antireflux therapy for chronic cough remains unclear, with most relevant trials reporting negative findings. This systematic review aimed to reevaluate the
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