Skip to Content
MilliporeSigma
All Photos(1)

Documents

PHR1294

Supelco

Chlorhexidine digluconate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Chlorhexidine digluconate solution, 1,6-Bis(N5-[p-chlorophenyl]-N1-biguanido)hexane; 1,1′-Hexamethylenebis(5-[p-chlorophenyl]biguanide)

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

CAS Number:
18472-51-0
MDL number:
MFCD00083599
UNSPSC Code:
41116107
PubChem Substance ID:
329823285
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to Ph. Eur. C1510000/1520000
traceable to USP 1111001/1111103

description

Chlorhexidine digluconate solution at approximately 20% in water

API family

chlorhexidine

CofA

current certificate can be downloaded

application(s)

pharmaceutical (small molecule)

format

single component solution

storage temp.

2-8°C

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1

InChI

1S/C22H30Cl2N10.2C6H12O7/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*7-1-2(8)3(9)4(10)5(11)6(12)13/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*2-5,7-11H,1H2,(H,12,13)/t;2*2-,3-,4+,5-/m.11/s1

InChI key

YZIYKJHYYHPJIB-UUPCJSQJSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Chlorhexidine digluconate may be used as a pharmaceutical reference standard for the determination of the analyte in eye drop formulations using capillary electrophoresis technique with contactless conductivity detection.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family. Its mechanism of action involves destabilization of the outer bacterial membrane. It is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0252 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.
Description
Pricing

PHR1222

Chlorhexidine acetate, Pharmaceutical Secondary Standard; Certified Reference Material

C1510000

Chlorhexidine, European Pharmacopoeia (EP) Reference Standard

C1520000

Chlorhexidine diacetate, European Pharmacopoeia (EP) Reference Standard

C1540000

Chlorhexidine dihydrochloride, European Pharmacopoeia (EP) Reference Standard

Y0001545

Chlorhexidine for system suitability, European Pharmacopoeia (EP) Reference Standard

PHR1421

Chlorhexidine, Pharmaceutical Secondary Standard; Certified Reference Material

1111103

Chlorhexidine acetate, United States Pharmacopeia (USP) Reference Standard

PHR1459

Chlorhexidine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

1111001

Chlorhexidine, United States Pharmacopeia (USP) Reference Standard

1111012

Chlorhexidine System Suitability Mixture, United States Pharmacopeia (USP) Reference Standard

BP068

Chlorhexidine acetate, British Pharmacopoeia (BP) Reference Standard

pictograms

CorrosionEnvironment
GHS05,GHS09

signalword

Danger

hcodes

H318,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD3712
LRAC7788
LRAC0252
LRAA9090
LRAA1627

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 5

1 of 5

vibrant-m

Y0001545

Chlorhexidine for system suitability

p-Chloroaniline Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1200

p-Chloroaniline

4-Chloroaniline PESTANAL®, analytical standard

Supelco

35823

4-Chloroaniline

USP

USP

1111012

Chlorhexidine System Suitability Mixture

Ascentis® RP-Amide HPLC Column 3 μm particle size, L × I.D. 10 cm × 2.1 mm

Supelco

565301-U

Ascentis® RP-Amide HPLC Column

Determination of chlorhexidine digluconate and polyhexamethylene biguanide in eye drops by capillary electrophoresis with contactless conductivity detection
Abad-Villar ME, et al.
Analytica Chimica Acta, 561(1-2), 133-137 (2006)
Luana Mafra Marti et al.
American journal of dentistry, 27(6), 318-322 (2015-02-25)
To evaluate the porosity, surface roughness and anti-biofilm activity of a glass-ionomer cement (GIC) after incorporation of different concentrations of chlorhexidine (CHX) gluconate or diacetate. For the porosity and surface roughness tests, 10 test specimens were fabricated of the GIC
Katie E Weichman et al.
Plastic and reconstructive surgery, 135(1), 9e-17e (2014-12-30)
To decrease the rate of infectious complications, surgeons have begun to use Biopatch (Ethicon, Somerville, N.J.) disks at drain exit sites. The authors investigated whether use of a Biopatch disk could convey a reduction in perioperative infections in patients undergoing
Chlorhexidine-based oral care and ventilator-associated pneumonia: the devil in disguise?
Marc J M Bonten
JAMA internal medicine, 174(5), 761-762 (2014-03-26)
Michael Klompas et al.
JAMA internal medicine, 174(5), 751-761 (2014-03-26)
Regular oral care with chlorhexidine gluconate is standard of care for patients receiving mechanical ventilation in most hospitals. This policy is predicated on meta-analyses suggesting decreased risk of ventilator-associated pneumonia, but these meta-analyses may be misleading because of lack of
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service