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PHR1461

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Copper Chlorophyllin

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Chlorophyllin sodium copper salt, Chlorophyllin, coppered trisodium salt

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About This Item

Empirical Formula (Hill Notation):
C34H31CuN4Na3O6
CAS Number:
11006-34-1
Molecular Weight:
724.15
EC Number:
234-242-5
UNSPSC Code:
41116107

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

API family

copper chlorophyllin

CofA

current certificate can be downloaded

packaging

pkg of 1 g

application(s)

pharmaceutical

format

neat

storage temp.

2-8°C

SMILES string

[Na+].[Na+].[Na+].CCc1c(C)c2cc3c(C=C)c(C)c4cc5nc(C(CCC([O-])=O)C5C)c(CC([O-])=O)c6c(C([O-])=O)c(C)c(cc1n2)n6[Cu]n34

InChI

1S/C34H36N4O6.Cu.3Na/c1-7-19-15(3)23-12-25-17(5)21(9-10-29(39)40)32(37-25)22(11-30(41)42)33-31(34(43)44)18(6)26(38-33)14-28-20(8-2)16(4)24(36-28)13-27(19)35-23;;;;/h7,12-14,17,21H,1,8-11H2,2-6H3,(H5,35,36,37,38,39,40,41,42,43,44);;;;/q;+2;3*+1/p-5

InChI key

HWDGVJUIHRPKFR-UHFFFAOYSA-I

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Copper chlorophyllin is a semi-synthetic derivative of natural chlorophyll pigment and is used as a common food colorant. It is usually synthesized by the alkaline hydrolysis of chlorophyll.

Application

Copper chlorophyllin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and food products by spectroscopy, and high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA3009 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD2384
LRAA3009

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Method development and HPLC analysis of retail foods and beverages for copper chlorophyll (E141 [i]) and chlorophyllin (E141 [ii]) food colouring materials
Scotter M
Food Additives and Contaminants, 22(12), 1163-1175 (2005)
HPLC-MS analysis of the green food colorant sodium copper chlorophyllin
Mortensen A and Geppel A
Innovative Food Science & Emerging Technologies, 8(3), 419-425 (2007)
Determination of copper (II) chlorophyllin by reversed-phase high-performance liquid chromatography
Inoue H, et al
Journal of Chromatography A, 679(1), 99-104 (1994)
Methods of analysis for food colour additive quality and safety assessment
Colour Additives for Foods and Beverages, 46(2), 131-188 (2015)
Copper chlorophyllin: A food colorant with bioactive properties?
Tumolo T, et al.
Food Research International, 46(2), 451-459 (2012)

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