Skip to Content
MilliporeSigma
All Photos(1)

Documents

PHR1487

Supelco

Kanamycin Sulfate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Kanamycin sulfate from Streptomyces kanamyceticus, Kanamycin A, Kanamycin sulfate salt

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C18H36N4O11 · H2O4S
CAS Number:
25389-94-0
Molecular Weight:
582.58
EC Number:
246-933-9
MDL number:
MFCD00070253
UNSPSC Code:
41116107
PubChem Substance ID:
329823411
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to BP 861
traceable to Ph. Eur. K0200000
traceable to USP 1355006

API family

kanamycin

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1

InChI key

OOYGSFOGFJDDHP-KMCOLRRFSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Kanamycin Sulfate, generated by specific strains of Streptomyces kanamyceticus, belongs to the class of aminoglycoside antibiotics. It is known to act effectively against a broad spectrum of Gram-negative and Gram-positive bacteria.

Application

Kanamycin Sulfate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding.

Mode of Resistance:Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes.

Antimicrobial spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7808 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360D

Hazard Classifications

Repr. 1B

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD4266
LRAB7808
LRAC9153
LRAB3627
LRAA3035

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 5

1 of 5

Kanamycin sulfate from Streptomyces kanamyceticus Animal Component-free

Sigma-Aldrich

K4000

Kanamycin sulfate from Streptomyces kanamyceticus

Supelco

Supelco

PHR1426

Spectinomycin Hydrochloride

Kanamycin solution from Streptomyces kanamyceticus 50 - 60 mg/mL in 0.9% NaCl, BioReagent, liquid, 0.1 μm filtered, suitable for cell culture

Sigma-Aldrich

K0254

Kanamycin solution from Streptomyces kanamyceticus

Gentamicin Sulfate Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1077

Gentamicin Sulfate

Tobramycin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1079

Tobramycin

Quantitative determination and separation of analogues of aminoglycoside antiobiotcs by high-performance liquid chromatography
Gambardella P, et al.
Journal of Chromatography A, 348(12), 229-240 (1985)
Development and validation of a novel LC/ELSD method for the quantitation of gentamicin sulfate components in pharmaceuticals
Megoulas NC and Koupparis MA
Journal of Pharmaceutical and Biomedical Analysis, 36(1), 73-79 (2004)
Development and validation of a novel LC non-derivatization method for the determination of amikacin in pharmaceuticals based on evaporative light scattering detection
Galanakis EG, et al.
Journal of Pharmaceutical and Biomedical Analysis, 40(5), 1114-1120 (2006)
Determination of aminoglycosides in pharmaceutical formulations-II. High-performance liquid chromatography
Fabre H, et al.
Journal of Pharmaceutical and Biomedical Analysis, 7(12), 1711-1718 (1989)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service