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PHR1509

Supelco

Epinephrine Bitartrate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

(−)-Epinephrine (+)-bitartrate salt, L-3,4-Dihydroxy-α-(methylaminomethyl)benzyl alcohol D-hydrogen bitartrate salt, L-Adrenaline (+)-bitartrate salt, L-Adrenaline D-hydrogentartrate, L-Epinephrine D-hydrogentartrate

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About This Item

Empirical Formula (Hill Notation):
C9H13NO3 · C4H6O6
CAS Number:
51-42-3
Molecular Weight:
333.29
EC Number:
200-097-1
MDL number:
MFCD00035077
UNSPSC Code:
41116107
PubChem Substance ID:
329823427
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to BP 3
traceable to Ph. Eur. A0300000
traceable to USP 1237000

API family

epinephrine

CofA

current certificate can be downloaded

packaging

ampule of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

O[C@H]([C@@H](O)C(O)=O)C(O)=O.CNC[C@H](O)c1ccc(O)c(O)c1

InChI

1S/C9H13NO3.C4H6O6/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;5-1(3(7)8)2(6)4(9)10/h2-4,9-13H,5H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t9-;1-,2-/m01/s1

InChI key

YLXIPWWIOISBDD-NDAAPVSOSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , ADRB1(153) , ADRB2(154) , ADRB3(155)

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Related Categories

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Epinephrine belongs to the class of drugs termed as catecholamines, which exerts its action on both alpha and beta-adrenergic receptors using a G protein-linked second messenger system.

Application

Epinephrine bitartrate may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Adrenergic receptor agonist.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0282 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 1 Oral

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAC0282
LRAB9591
LRAA3316

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L-(–)-Epinephrine-(+)-bitartrate α,β-Adrenergic receptor agonist.

Sigma-Aldrich

324900

L-(–)-Epinephrine-(+)-bitartrate

Adrenaline tartrate with impurity A European Pharmacopoeia (EP) Reference Standard

Y0000707

Adrenaline tartrate with impurity A

(±)-Epinephrine hydrochloride

Sigma-Aldrich

E4642

(±)-Epinephrine hydrochloride

(−)-Epinephrine

Sigma-Aldrich

E4250

(−)-Epinephrine

Adrenaline European Pharmacopoeia (EP) Reference Standard

Y0000882

Adrenaline

L-(−)-Norepinephrine (+)-bitartrate salt monohydrate meets USP testing specifications

Sigma-Aldrich

N5785

L-(−)-Norepinephrine (+)-bitartrate salt monohydrate

Quantitative high-pressure liquid chromatographic determination of epinephrine in pharmaceutical formulations
Fu CC and Sibley MJ
Journal of Pharmaceutical Sciences, 66(3), 425-426 (1977)
Determination of catecholamines by flow-injection analysis and high-performance liquid chromatography with chemiluminescence detection
Nalewajko E, et al.
Journal of Pharmaceutical and Biomedical Analysis, 43(5), 1673-1681 (2007)
Epinephrine
StatPearls [Internet] (2019)
A reversed-phase high performance liquid chromatographic method for determination of Epinephrine in pharmaceutical formulation
Mishra AK, et al
Archives of Applied Science Research, 2, 251-256 (2010)

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