Skip to Content
MilliporeSigma
All Photos(1)

Documents

PHR1555

Supelco

Hexane

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Hexane, n-Hexane

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
CH3(CH2)4CH3
CAS Number:
110-54-3
Molecular Weight:
86.18
Beilstein/REAXYS Number:
1730733
EC Number:
203-777-6
MDL number:
MFCD00009520
UNSPSC Code:
41116107
PubChem Substance ID:
329823464
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to USP 1601601

vapor density

~3 (vs air)

vapor pressure

256 mmHg ( 37.7 °C)
5.2 psi ( 37.7 °C)
~132 mmHg ( 20 °C)

CofA

current certificate can be downloaded

autoignition temp.

453 °F

expl. lim.

7.7 %

packaging

ampule of 3x1.2 mL

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.375 (lit.)

bp

69 °C (lit.)

mp

−95 °C (lit.)

density

0.659 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CCCCCC

InChI

1S/C6H14/c1-3-5-6-4-2/h3-6H2,1-2H3

InChI key

VLKZOEOYAKHREP-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Hexane is a non-polar organic solvent and a straight-chain alkane with six carbon atoms. It belongs to the Class 2 category of organic solvents, as per United States Pharmacopoeia. It has limited application in the synthesis of pharmaceuticals, due to its moderate toxicity.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Hexane may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by gas chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB5023 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

signalword

Danger

Hazard Classifications

Aquatic Chronic 2 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 Inhalation - STOT SE 3

target_organs

Central nervous system, Nervous system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

-7.6 °F

flash_point_c

-22 °C

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAC7311
LRAB3835
LRAB5023
LRAA4471

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 6

1 of 6

Toluene Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1311

Toluene

Acetone Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1219

Acetone

Hexane HPLC Plus, for HPLC, GC, and residue analysis, ≥95%

Sigma-Aldrich

675393

Hexane

n-Hexane reference substance for gas chromatography

Supelco

1.09687

n-Hexane

Methanol Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1372

Methanol

Cyclohexane Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1687

Cyclohexane

?467? Residual Solvents
USP43/NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 45(3)(9), 6712-6712 (2019)
Green process chemistry in the pharmaceutical industry
Cue BW and Zhang J
Green Chemistry Letters and Reviews, 2(4), 193-211 (2009)
What is a green solvent? A comprehensive framework for the environmental assessment of solvents
Capello C, et al.
Green Chemistry, 9(9), 927-934 (2007)
A generic static headspace gas chromatography method for determination of residual solvents in drug substance.
Cheng, et al.
Journal of Chromatography A, 1217(41), 6413-6421 (2010)

Protocols

GC Analysis of Total Petroleum Hydrocarbons (TPH) on SLB®-5ms

Separation of Hexane; Heptane; Octane; Nonane; Decane; Undecane; Dodecane; Tetradecane; Hexadecane; Octadecane; Eicosane; Tetracosane; Octacosane; Dotriacontane; Hexatriacontane; Tetracontane; Tetratetracontane

GC Analysis of Class 2 Residual Solvents on OVI-G43

GC Analysis of Class 2 Residual Solvents on OVI-G43

GC Analysis of Hydrocarbons in Gasoline on Petrocol® DH

Protocol for GC Analysis of Hydrocarbons in Gasoline on Petrocol® DH

GC Analysis of Hydrocarbons in Gasoline on Equity®-1 (15 m x 0.10 mm I.D., 0.10 μm), Fast GC Analysis

-Xylene; Nonane; Propylbenzene; Mesitylene; 1,2,4-Trimethylbenzene; 1,2,3-Trimethylbenzene; 1,3-Diethylbenzene; 1,4-Dimethyl-2-ethylbenzene; 1,2-Dimethyl-4-ethylbenzene; Durene; 1,2,3,5-Tetramethylbenzene; 1,2,3,5-Tetramethylbenzene; 2-Methylnaphthalene (β)

See All

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service