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PHR1590

Supelco

Bacitracin

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Bacitracin

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About This Item

Empirical Formula (Hill Notation):
C66H103N17O16S
CAS Number:
1405-87-4
Molecular Weight:
1422.69
EC Number:
215-786-2
MDL number:
MFCD00062640
UNSPSC Code:
41116107
PubChem Substance ID:
329823496

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to USP 1048007

API family

bacitracin

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

221-225 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

SMILES string

CCC(C)C(N)C1=NC(CS1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H]2CCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](Cc4ccccc4)NC(=O)[C@@H](NC(=O)[C@@H](CCCN)NC2=O)[C@@H](C)CC

InChI

1S/C66H103N17O16S/c1-9-35(6)52(69)66-81-48(32-100-66)63(97)76-43(26-34(4)5)59(93)74-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)75-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-72-39)77-60(94)44(27-38-18-13-12-14-19-38)80-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)73-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,72)(H,71,89)(H,73,90)(H,74,93)(H,75,98)(H,76,97)(H,77,94)(H,78,96)(H,79,95)(H,80,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35?,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48?,52?,53-,54-/m0/s1

InChI key

CLKOFPXJLQSYAH-RNHDWVCBSA-N

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General description

Bacitracin is a polypeptide antibiotic recovered from certain strains of B. subtilis and B. licheniformis. Its mode of action involves the inhibition of bacterial cell wall synthesis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Bacitracin may be used as a pharmaceutical secondary reference standard for the determination of the analyte in serum samples and food samples by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA4581 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAC9792
LRAC0580
LRAC9792
LRAC0580
LRAA4581

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Sigma-Aldrich

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Bacitracin: a new antibiotic produced by a member of the B. subtilis group
Johnson BA, et al.
Science (New York, N.Y.), 102(2650), 376-377 (1945)
Analysis of major components of residual bacitracin and colistin in food samples by liquid chromatography tandem mass spectrometry
Sin DW, et al.
Analytica Chimica Acta, 535(1-2), 23-31 (2005)
Bacitracin: an inhibitor of the dephosphorylation of lipid pyrophosphate, an intermediate in the biosynthesis of the peptidoglycan of bacterial cell walls
Siewert G and Strominger JL
Proceedings of the National Academy of Sciences of the USA, 57(3), 767-767 (1967)
Determination of neomycin and bacitracin in human or rabbit serum by HPLC--MS/MS
Mascher DG, et al.
Journal of Pharmaceutical and Biomedical Analysis, 43(2), 691-700 (2007)

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