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PHR1611

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Mercaptopurine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

6-Mercaptopurine monohydrate, 6-Purinethiol, 6-Thiohypoxanthine

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About This Item

Empirical Formula (Hill Notation):
C5H4N4S·H2O
CAS Number:
6112-76-1
Molecular Weight:
170.19
Beilstein/REAXYS Number:
4012091
EC Number:
200-037-4
MDL number:
MFCD03854445
UNSPSC Code:
41116107
PubChem Substance ID:
329823508
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

API family

mercaptopurine

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

O.S=C1NC=Nc2nc[nH]c12

InChI

1S/C5H4N4S.H2O/c10-5-3-4(7-1-6-3)8-2-9-5;/h1-2H,(H2,6,7,8,9,10);1H2

InChI key

WFFQYWAAEWLHJC-UHFFFAOYSA-N

Gene Information

human ... PPAT(5471)

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Mercaptopurine is an anticancer and an immunosuppressive drug employed for the management of acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn′s disease, etc. Its mode of action involves interference in the nucleic acid synthesis by the inhibition of purine metabolism.

Application

Mercaptopurine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, suspensions, and double drug liposomes by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3476 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Muta. 2 - Repr. 2

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD2225
LRAC3476
LRAA4870

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Sigma-Aldrich

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Mercaptopurine impurity standard British Pharmacopoeia (BP) Reference Standard

BP762

Mercaptopurine impurity standard

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Y0000441

Didanosine impurity A,

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF MERCAPTOPURINE-AN ANTI CANCER DRUG IN PHARMACEUTICAL FORMULATIONS
Suman P, et al.
European Journal of Biomedical AND Pharmaceutical sciences, 5(5), 752-759 (2018)
Effect of buffer and antioxidant on stability of a mercaptopurine suspension
Aliabadi HM, et al.
American Journal of Health-System Pharmacy, 65(5), 441-447 (2008)
6-mercaptopurine and daunorubicin double drug liposomes?preparation, drug-drug interaction and characterization
Agrawal V, et al.
Journal of liposome research, 15(3-4), 141-155 (2005)
Mepivacaine hydrochloride
USP42-NF37
United States Pharmacopeia/National Formulary, 40(5), 2750-2750 (2019)

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