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PHR1632

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Pioglitazone hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Pioglitazone hydrochloride, 5-[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]benzyl]thiazolidine-2,4-dione hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H20N2O3S · HCl
CAS Number:
112529-15-4
Molecular Weight:
392.90
MDL number:
MFCD04975446
UNSPSC Code:
41116107
PubChem Substance ID:
329823522
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to Ph. Eur. Y0001520
traceable to USP 1539905

API family

pioglitazone

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

190-195.5 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C19H20N2O3S.ClH/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17;/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23);1H

InChI key

GHUUBYQTCDQWRA-UHFFFAOYSA-N

Gene Information

human ... PPARG(5468)

Related Categories

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Pioglitazone hydrochloride is an oral antidiabetic agent used in the treatment of type 2 diabetes mellitus (also known as non-insulin-dependent diabetes mellitus (NIDDM) or adult-onset diabetes.

Application

Pioglitazone hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Selective PPARγ agonist

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB3624 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAA5299
LRAB3624
LRAC4119

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Sigma-Aldrich

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Sigma-Aldrich

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Determination of pioglitazone hydrochloride in bulk and pharmaceutical formulations by UV spectrophotometric method.
Shakya P and Singh K
International Journal of Pharmaceutical Sciences and Research, 1(11), 153-153 (2010)
Development and validation of new RPHPLC method for determination of pioglitazone hcl in pharmaceutical dosage forms.
Srinivasulu D, et al.
International journal of chemistry research, 1(1), 18-20 (2010)
Determination of pioglitazone hydrochloride in bulk and pharmaceutical formulations by HPLC and MEKC methods.
Radhakrishna T, et al.
Journal of Pharmaceutical and Biomedical Analysis, 29(4), 593-607 (2002)
Simultaneous estimation of metformin hydrochloride, pioglitazone hydrochloride, and glimepiride by RP-HPLC in tablet formulation.
Jain D, et al.
Journal of Chromatographic Science, 46(6), 501-504 (2008)

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