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PHR1666

Supelco

Diethyl Ether

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Diethyl ether, Ether, Ethyl ether

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About This Item

Linear Formula:
(CH3CH2)2O
CAS Number:
60-29-7
Molecular Weight:
74.12
Beilstein/REAXYS Number:
1696894
EC Number:
200-467-2
MDL number:
MFCD00011646
UNSPSC Code:
41116107
PubChem Substance ID:
329823542
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

vapor density

2.6 (vs air)

CofA

current certificate can be downloaded

autoignition temp.

320 °F

quality

pharmaceutical secondary standard

expl. lim.

36.5 %

packaging

pkg of 3 × 1.2 mL

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.3530 (lit.)

bp

34.6 °C (lit.)

mp

−116 °C (lit.)

density

0.706 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CCOCC

InChI

1S/C4H10O/c1-3-5-4-2/h3-4H2,1-2H3

InChI key

RTZKZFJDLAIYFH-UHFFFAOYSA-N

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General description

Diethyl ether is a non-polar volatile organic solvent, commonly used as an extraction solvent in liquid-liquid extraction for separation of post reaction residues from synthetic products.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Diethyl ether may be used as a solvent reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by gas chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0145 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Flam. Liq. 1 - STOT SE 3

target_organs

Central nervous system

supp_hazards

EUH019,EUH066

wgk_germany

WGK 1

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD4372
LRAD2333
LRAC6098
LRAC4506
LRAC0145

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Diethyl ether EMPROVE® ESSENTIAL, Ph. Eur., BP

SAFC

1.00926

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Diethyl ether puriss., contains ~5 mg/L 2,6-di-tert.-butyl-4-methylphenol as stabilizer, meets analytical specification of Ph. Eur., BP, ≥99.5% (GC)

Sigma-Aldrich

24004

Diethyl ether

Diethyl ether reagent grade, ≥98%, contains ≤2% ethanol and ≤10ppm BHT as inhibitor

Sigma-Aldrich

346144

Diethyl ether

Diethyl ether suitable for HPLC, ≥99.9%, inhibitor-free

Sigma-Aldrich

309966

Diethyl ether

Butyl acetate Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1211

Butyl acetate

Diethyl ether contains 1 ppm BHT as inhibitor, anhydrous, ≥99.7%

Sigma-Aldrich

296082

Diethyl ether

Residual solvent testing: a review of gas-chromatographic and alternative techniques
B'Hymer C
Pharmaceutical Research, 20(3), 337-344 (2003)
Determination of residual solvent levels in bulk pharmaceuticals by capillary gas chromatography
Smith ID and Waters DG
Analyst, 116(12), 1327-1331 (1991)
Organic solvents in the pharmaceutical industry
Grodowska K and Parczewski A
Acta Poloniae Pharmaceutica, 67(1), 3-12 (2010)

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