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PHR1710

Supelco

Cetirizine hydrochloride Related Compound A

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Cetirizine ethyl ester dihydrochloride, (RS)-2-[2-[4-[(4-chlorophenyl)phenylmethyl]piperazin-1-yl]ethoxy]acetic acid ethyl ester dihydrochloride (Cetirizine hydrochloride Related Compound A), (RS)-2-[2-[4-[(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]ethoxy]acetic acid ethyl ester dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C23H29ClN2O3 · 2HCl
CAS Number:
246870-46-2
Molecular Weight:
489.86
EC Number:
206-137-4
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to USP 1102930

API family

cetirizine

CofA

current certificate can be downloaded

packaging

pkg of 40 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

InChI

1S/C23H29ClN2O3/c1-2-29-22(27)18-28-17-16-25-12-14-26(15-13-25)23(19-6-4-3-5-7-19)20-8-10-21(24)11-9-20/h3-11,23H,2,12-18H2,1H3

InChI key

ASHQTVRYHSZGQY-UHFFFAOYSA-N

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General description

Cetirizine hydrochloride Related Compound A is an impurity of cetirizine hydrochloride. Cetirizine hydrochloride is a second-generation antihistamine compound. It is a major metabolite of hydroxyzine that exhibits high specific affinity for histamine H1 receptor. It is used for the management of allergies, hay fever, angioedema, and urticaria.
Pharmaceutical secondary standard for application in quality control. Provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Cetirizine hydrochloride has been used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry and chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA7298 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

C0980650

Cetirizine dihydrochloride, European Pharmacopoeia (EP) Reference Standard

C0980651

Cetirizine impurity A, European Pharmacopoeia (EP) Reference Standard

Y0001197

Cetirizine for peak identification, European Pharmacopoeia (EP) Reference Standard

1102929

Cetirizine dihydrochloride, United States Pharmacopeia (USP) Reference Standard

1102930

Cetirizine Related Compound A, United States Pharmacopeia (USP) Reference Standard

PHR1656

Cetirizine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

1112467

4-Chlorobenzophenone, United States Pharmacopeia (USP) Reference Standard

1102952

Cetirizine Related Compound C, United States Pharmacopeia (USP) Reference Standard

1102941

Cetirizine Related Compound B, United States Pharmacopeia (USP) Reference Standard

1102963

Cetirizine Related Compound G, United States Pharmacopeia (USP) Reference Standard

BP837

Cetirizine hydrochloride, British Pharmacopoeia (BP) Reference Standard

BP1081

Cetirizine impurity standard, British Pharmacopoeia (BP) Reference Standard

BP441

1,4-Bis(4-chlorobenzhydryl)piperazine, British Pharmacopoeia (BP) Reference Standard

PHR2852

Cetirizine Related Compound G, certified reference material, pharmaceutical secondary standard

PHR3195

Levocetirizine Dihydrochloride, pharmaceutical secondary standard, certified reference material

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H302,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAC9869
LRAC0705
LRAA7298

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Cetirizine dihydrochloride European Pharmacopoeia (EP) Reference Standard

C0980650

Cetirizine dihydrochloride

Cetirizine for peak identification European Pharmacopoeia (EP) Reference Standard

Y0001197

Cetirizine for peak identification

Cetirizine dihydrochloride ≥98% (HPLC)

Sigma-Aldrich

C3618

Cetirizine dihydrochloride

Norphenylephrine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1536

Norphenylephrine Hydrochloride

Levocetirizine dihydrochloride ≥98% (HPLC)

Sigma-Aldrich

L7795

Levocetirizine dihydrochloride

Phenylephrine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1017

Phenylephrine Hydrochloride

Simultaneous quantitation and validation of paracetamol, phenylpropanolamine hydrochloride and cetirizine hydrochloride by RP-HPLC in bulk drug and formulation
Suryan AL, et al.
International Journal of Pharmaceutical Sciences and Drug Research, 3(4), 303-308 (2011)
Determination and quantification of cetirizine HCl in dosage formulations by RP-HPLC
Wankhede SB, et al.
International Journal of Pharmaceutical Sciences and Drug Research, 4(3), 222-226 (2012)
Development and Validation of RP-HPLC Method for Simultaneous Estimation of Cetirizine Hydrochloride and Phenylpropanolamine Hydrochloride in Tablet Dosage Form.
Dhongle PS, et al.
Research Journal of Pharmacy and Technology, 4(9), 1471-1474 (2011)
RP-HPLC and spectrophotometric estimation of ambroxol hydrochloride and cetirizine hydrochloride in combined dosage form.
Bhatia NM, et al.
Indian Journal of Pharmaceutical Sciences, 70(5), 603-603 (2008)
Determination and quantification of cetirizine HCl in dosage formulations by RP-HPLC.
ARAYNE MS, et al.
Science, 1(4), 1-4 (2005)

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