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PHR1720

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Clomipramine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Clomipramine hydrochloride, 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, Anafranil hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H23ClN2 · HCl
CAS Number:
17321-77-6
Molecular Weight:
351.31
EC Number:
241-344-3
MDL number:
MFCD00069234
UNSPSC Code:
41116107
PubChem Substance ID:
329823573
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to BP
traceable to Ph. Eur. C2360000
traceable to USP 1140427

API family

clomipramine

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl.CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13

InChI

1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H

InChI key

WIMWMKZEIBHDTH-UHFFFAOYSA-N

Gene Information

human ... SLC6A4(6532)

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Clomipramine hydrochloride is one of the dibenzazepine tricyclic antidepressants that inhibits noradrenalin and serotonin reuptake in central nervous system. It also shows antimuscarinic properties.

Application

Clomipramine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in traditional Chinese medicine and pharmaceutical formulations by analytical and cyclodextrin-modified capillary zone electrophoresis techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3902 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

C2360000

Clomipramine hydrochloride, for microbiological assay, European Pharmacopoeia (EP) Reference Standard

Y0000132

Clomipramine impurity C, European Pharmacopoeia (EP) Reference Standard

Y0000134

Clomipramine impurity F, European Pharmacopoeia (EP) Reference Standard

Y0000133

Clomipramine impurity D, European Pharmacopoeia (EP) Reference Standard

1140247

Clomipramine hydrochloride, United States Pharmacopeia (USP) Reference Standard

1140292

Clomipramine Related Compound F, United States Pharmacopeia (USP) Reference Standard

1140269

Clomipramine Related Compound C, United States Pharmacopeia (USP) Reference Standard

1140270

Clomipramine Related Compound D, United States Pharmacopeia (USP) Reference Standard

BP980

Clomipramine hydrochloride, British Pharmacopoeia (BP) Reference Standard

BP982

Clomipramine impurity D, British Pharmacopoeia (BP) Reference Standard

BP983

Clomipramine impurity F, British Pharmacopoeia (BP) Reference Standard

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 1 - STOT SE 3

target_organs

Central nervous system, Central nervous system,Cardiovascular

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD5647
LRAA7394
LRAC3902
LRAC6353

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Multicommutated flow system for the chemiluminometric determination of clomipramine in pharmaceutical preparations.
Marques KL, et al.
Analytica Chimica Acta, 518(1-2), 31-36 (2004)
Method for simultaneous determination of eight cyclic antidepressants by cyclodextrin-modified capillary zone electrophoresis: applications in pharmaceuticals.
Kou HS, et al.
Analytica Chimica Acta, 525(1), 23-30 (2004)
HPLC and GC?MS screening of Chinese proprietary medicine for undeclared therapeutic substances.
Liu SY, et al.
Journal of Pharmaceutical and Biomedical Analysis, 24(5-6), 983-992 (2001)

Articles

HPLC Analysis of Tricyclic Antidepressants on Ascentis® Express 2.7 μm RP-Amide

-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder; Norclomipramine hydrochloride, ~99% (TLC), powder; Imipramine hydrochloride solution, drug standard, 1.0 mg/mL in methanol; Amitriptyline hydrochloride, ≥98% (TLC), powder; Clomipramine hydrochloride, ≥98% (HPLC), powder

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