PHR1752
Bupropion Hydrochloride Related Compound A
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(s):
2-(tert-Butylamino)-4′-chloropropiophenone hydrochloride, 2-(tert-butylamino)-3’-bromopiophenone hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C13H18ClNO · HCl
CAS Number:
Molecular Weight:
276.20
UNSPSC Code:
41116107
NACRES:
NA.24
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grade
certified reference material
pharmaceutical secondary standard
Quality Level
agency
traceable to USP 1078744
API family
bupropion
CofA
current certificate can be downloaded
packaging
pkg of 30 mg
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
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General description
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Bupropion hydrochloride (BUP) and its derivatives belong to a chemical class of aminoketones and are known for their antidepressant abilities. BUP selectively inhibits the neuronal reabsorption of catecholamines (noradrenalin and dopamine), has minimal effect on the recapture of indolamines (serotonin) and no inhibitory effect on monoamine oxidase. It is used as the non-nicotine pharmacological therapy for combating smoking in controlled release form.
Bupropion hydrochloride (BUP) may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric and chromatographic techniques.
Bupropion hydrochloride (BUP) and its derivatives belong to a chemical class of aminoketones and are known for their antidepressant abilities. BUP selectively inhibits the neuronal reabsorption of catecholamines (noradrenalin and dopamine), has minimal effect on the recapture of indolamines (serotonin) and no inhibitory effect on monoamine oxidase. It is used as the non-nicotine pharmacological therapy for combating smoking in controlled release form.
Bupropion hydrochloride (BUP) may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric and chromatographic techniques.
Application
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Footnote
To see an example of a Certificate of Analysis for this material enter LRAA7916 in the slot below. This is an example certificate only and may not be the lot that you receive.
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Product No.
Description
Pricing
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Use of charge transfer complexation reaction for the spectrophotometric determination of bupropion in pharmaceuticals and spiked human urine.
Basavaiah K and Abdulrahman SAM
The Thai Journal of Pharmaceutical Sciences, 34(4), 257-261 (2010)
Spectroscopic investigations on the inclusion interaction between hydroxypropyl-β-cyclodextrin and bupropion
Misiuk W and Zalewska M
Journal of Molecular Liquids, 159(3), 220-225 (2011)
Titrimetric and spectrophotometric assay of bupropion hydrochloride in pharmaceuticals using mercury (II) nitrate
Abdulaziz MA, et al.
Ecletica Quimica, 35(3), 9-16 (2010)
Determination of bupropion using liquid chromatography with fluorescence detection in pharmaceutical preparations, human plasma and human urine
Ulu ST and Tuncel M
Journal of Chromatographic Science, 50(5), 433-439 (2012)
Structures from powders: Bupropion hydrochloride
Maccaroni E, et al
Journal of Pharmaceutical and Biomedical Analysis, 50(2), 257-261 (2009)
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