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PHR2025

Supelco

Desbenzyl donepezil hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

5,6-Dimethoxy-2-(piperidin-4-ylmethyl)indan-1-one hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C17H23NO3 · HCl
CAS Number:
120013-39-0
Molecular Weight:
325.83
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to USP 1171819

API family

donepezil

CofA

current certificate can be downloaded

packaging

pkg of 50 mg

application(s)

pharmaceutical

format

neat

storage temp.

2-8°C

InChI

1S/C17H23NO3.ClH/c1-20-15-9-12-8-13(7-11-3-5-18-6-4-11)17(19)14(12)10-16(15)21-2;/h9-11,13,18H,3-8H2,1-2H3;1H

InChI key

WOZXDQQCMZIQEG-UHFFFAOYSA-N

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General description

Desbenzyl donepezil hydrochloride is a metabolite of drug, donepezil hydrochloride. Donepezil hydrochloride is a neurocognition-enhancing drug prescribed especially to manage dementia during Alzheimer′s disease.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Donepezil hydrochloride can be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB4752 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

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Pricing

1224992

Donepezil related compound A, United States Pharmacopeia (USP) Reference Standard

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Donepezil hydrochloride, United States Pharmacopeia (USP) Reference Standard

PHR1584

Donepezil Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

1171819

Desbenzyl donepezil hydrochloride, United States Pharmacopeia (USP) Reference Standard

1224970

Donepezil-N-oxide, United States Pharmacopeia (USP) Reference Standard

PHR2023

(E)-2-[(1-Benzylpiperidin-4-yl)methylene]-5,6-dimethoxyindan-1-one(Donepezil Related Compound A), Pharmaceutical Secondary Standard; Certified Reference Material

PHR2024

Donepezil-N-Oxide, Pharmaceutical Secondary Standard; Certified Reference Material

Y0002165

Donepezil for system suitability, CRS, European Pharmacopoeia (EP) Reference Standard

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Donepezil hydrochloride, CRS, European Pharmacopoeia (EP) Reference Standard

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD5549
LRAB4752

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Find documentation for the products that you have recently purchased in the Document Library.

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Determination of donepezil hydrochloride in human plasma and pharmaceutical formulations by HPLC with fluorescence detection
Abonassif M, et al
Acta pharmaceutica, 61(4), 403-413 (2011)
RP-HPLC method for the estimation of donepezil hydrochloride dosage form
Barot TG and Patel PK
Journal of Chemistry, 6(2), 594-600 (2009)
Donepezil for dementia due to Alzheimer's disease
Birks JS and Harvey RJ
Cochrane database of systematic reviews (Online) (2018)
A new HPLC method to determine Donepezil hydrochloride in tablets.
Pappa H, et al.
Journal of Pharmaceutical and Biomedical Analysis, 27(1-2), 177-182 (2002)

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