SMB00947
N-Desethyl amodiaquine dihydrochloride
≥95%
Synonym(s):
Monodesethylamodiaquine dihydrochloride
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About This Item
Empirical Formula (Hill Notation):
C18H18ClN3O · 2HCl
CAS Number:
Molecular Weight:
400.73
UNSPSC Code:
41116107
NACRES:
NA.77
Recommended Products
biological source
synthetic
Quality Level
assay
≥95%
form
solid
mol wt
400.73 g/mol
technique(s)
HPLC: suitable
color
yellow to dark yellow
solubility
DMSO: soluble
methanol: soluble
water: soluble
storage temp.
2-8°C
Application
Amodiaquine (AQ) is currently used in combination with Artesunate (AS) as first-line treatment for some cases of falciparum malaria (UM) in many countries. AQ is metabolized by hepatic cytochrome P450 2C8 (CYP2C8) to Desethylamodiaquine (DAQ; DEAQ; NADQ; Ndes-amo), which is subsequently eliminated via extra-hepatic biotransformation by CYP1A1 and CYP1B1. DEAQ is responsible for the pharmacological activity of AQ (both therapeutic and toxicity) due to its long elimination half-life.
Metabolomics research
Other Notes
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wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Ahmed A Albassam et al.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 27(3), 406-412 (2019-04-13)
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Yingshan Han et al.
Journal of medical virology, 91(7), 1182-1190 (2019-02-26)
Studies aimed at repurposing existing drugs revealed that some antimalarial compounds possess anti-Zika virus (anti-ZIKV) activity. Here, we further tested 14 additional antimalarial drugs and their metabolites or analogs for anti-ZIKV activity using a phenotypic screening approach. We identified four
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