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V0500

Sigma-Aldrich

L-Valine

≥98% (HPLC), suitable for thin layer chromatography (TLC)

Synonym(s):

(S)-α-Aminoisovaleric acid, L-2-Amino-3-methylbutanoic acid

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About This Item

Linear Formula:
(CH3)2CHCH(NH2)CO2H
CAS Number:
72-18-4
Molecular Weight:
117.15
Beilstein/REAXYS Number:
1721136
EC Number:
200-773-6
MDL number:
MFCD00064220
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24900695
NACRES:
NA.26

product name

L-Valine, reagent grade, ≥98% (HPLC)

grade

reagent grade

Quality Level

200

assay

≥98% (HPLC)

form

powder

technique(s)

thin layer chromatography (TLC): suitable

color

white

mp

295-300 °C (subl.) (lit.)

solubility

H2O: 50 mg/mL, clear, colorless

SMILES string

CC(C)[C@H](N)C(O)=O

InChI

1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1

InChI key

KZSNJWFQEVHDMF-BYPYZUCNSA-N

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Application

  • L-Valine has been used as a standard in thin layer chromatography.
  • It has been used as a supplement in Grace′s antheraea medium for the culture of cells and tissue from invertebrates.
  • It has been used in the preparation of starvation media to study the role of relA gene in antibiotic resistance in E. coli.

Biochem/physiol Actions

Valine is an essential amino acid, involved in the biosynthesis of glutamine and alanine. Valine being a branched-chain amino acid (BCAA) maintains a balance among the BCAAs. L-Valine serves as an energy fuel. Long term deficiency of L-Valine leads to growth failure, organ damage and loss of muscle mass.

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Preparation of several media for the culture of tissues and cells from invertebrates.
Vaughn
TCA Manual, 527-537 (1977)
Martin Kohlmeier
Nutrient Metabolism: Structures, Functions, and Genes, 390-390 (2015)
On the limited role of relA in kanamycin and amino acid starvation induced stringency and subsequent antibiotic cross-protection in Escherichia coli
Chiang
Journal of Experimental Microbiology and Immunology, 15, 59-63 (2011)
Zhe Yang et al.
Cell research, 28(10), 1013-1025 (2018-09-14)
Adequate protein intake is crucial for the survival and well-being of animals. How animals assess prospective protein sources and ensure dietary amino acid intake plays a critical role in protein homeostasis. By using a quantitative feeding assay, we show that
Sonia Jego et al.
Nature neuroscience, 16(11), 1637-1643 (2013-09-24)
Rapid-eye movement (REM) sleep correlates with neuronal activity in the brainstem, basal forebrain and lateral hypothalamus. Lateral hypothalamus melanin-concentrating hormone (MCH)-expressing neurons are active during sleep, but their effects on REM sleep remain unclear. Using optogenetic tools in newly generated
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