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Y0000396

Granisetron hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C18H24N4O· HCl
CAS Number:
107007-99-8
Molecular Weight:
348.87
MDL number:
MFCD01747034
UNSPSC Code:
41116107
PubChem Substance ID:
329830931
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

granisetron

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl.CN1[C@H]2CCC[C@@H]1C[C@@H](C2)NC(=O)c3nn(C)c4ccccc34

InChI

1S/C18H24N4O.ClH/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17;/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23);1H/t12-,13+,14-;

InChI key

QYZRTBKYBJRGJB-WQTKJZBYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Granisetron hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Granisetron hydrochloride is a serotonin 5-HT3 receptor antagonist and antiemetic.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

Y0000395

Granisetron impurity E, European Pharmacopoeia (EP) Reference Standard

Y0000477

Granisetron impurity A, European Pharmacopoeia (EP) Reference Standard

Y0000478

Granisetron impurity B, European Pharmacopoeia (EP) Reference Standard

1298140

Granisetron Related Compound D, United States Pharmacopeia (USP) Reference Standard

1298117

Granisetron Related Compound A, United States Pharmacopeia (USP) Reference Standard

1298128

Granisetron Related Compound B, United States Pharmacopeia (USP) Reference Standard

1298106

Granisetron hydrochloride, United States Pharmacopeia (USP) Reference Standard

1298139

Granisetron Related Compound C, United States Pharmacopeia (USP) Reference Standard

1298150

Granisetron Related Compound E, United States Pharmacopeia (USP) Reference Standard

1298092

Granisetron, United States Pharmacopeia (USP) Reference Standard

PHR2871

Granisetron Related Compound D, pharmaceutical secondary standard, certified reference material

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Caroline Sévoz-Couche et al.
The Journal of physiology, 591(7), 1871-1887 (2013-01-09)
Anxiety disorders in humans reduce both the heart rate variability (HRV) and the sensitivity of the cardiac baroreflex (BRS). Both may contribute to sudden death. To elucidate the mechanisms underlying these alterations, male rats were subjected to social defeat sessions
Yaqiong Wang et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 105, 612-617 (2013-02-09)
In 0.1 mol L(-1) HCl medium, antiemetic drugs (ATM), such as granisetron hydrochloride (GS) and tropisetron hydrochloride (TS), reacted with H(3)PW(12)O(40)·nH(2)O and formed 3:1 ion-association complex of [(ATM)(3)PW(12)O(40)], then self-aggregated into nanoparticles-[(ATM)(3)PW(12)O(40)](n) with an average size of 100 nm. The
Su Mi Park et al.
Reviews in the neurosciences, 23(5-6), 555-569 (2012-10-23)
The changes in serotonin type 3 (5-HT) receptor activity influence memory and emotional regulation,the two essential components underlying the successful extinction of conditioned fear. These studies determined if blocking 5-HT3 receptors with granisetron influences the extinction of fear in male
Divya Kesters et al.
EMBO reports, 14(1), 49-56 (2012-12-01)
The 5-HT(3) receptor is a pentameric serotonin-gated ion channel, which mediates rapid excitatory neurotransmission and is the target of a therapeutically important class of anti-emetic drugs, such as granisetron. We report crystal structures of a binding protein engineered to recognize
Yuko Horii et al.
Neuroscience letters, 539, 32-37 (2013-02-09)
Lactobacilli provide several health benefits to mammals, including humans. We previously observed that in rats, intraduodenal injection of Lactobacillus johnsonii La1 elevated efferent gastric vagal nerve activity (efferent-GVNA), while Lactobacillus paracasei ST11 suppressed efferent-GVNA, and thereby increased or decreased food
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