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Y0000487

Leflunomide impurity A

Name: Leflunomide impurity A
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

4-(Trifluoromethyl)aniline, α,α,α-Trifluoro-p-toluidine, 4-Aminobenzotrifluoride

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About This Item

Linear Formula:

CF₃C₆H₄NH₂

CAS Number:

455-14-1

Molecular Weight:

161.12

Beilstein/REAXYS Number:

1564853

MDL number:

MFCD00064396

UNSPSC Code:

41116107

PubChem Substance ID:

329830979

NACRES:

NA.24

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USP

1357045

Leflunomide Related Compound A

Y0002254

Teriflunomide impurity B

USP

1357067

Leflunomide Related Compound C

Y0002253

Teriflunomide for assay

Supelco

PHR1568

Leflunomide Related Compound A

Y0000221

Fluticasone impurity D

USP

1357056

Leflunomide Related Compound B

Sigma-Aldrich

SML0936

Teriflunomide

Supelco

PHR2878

Leflunomide Related Compound B

L0399905

Levocarnitine impurity A

grade

pharmaceutical primary standard

API family

leflunomide

manufacturer/tradename

EDQM

refractive index

n20/D 1.483 (lit.)

bp

83 °C/12 mmHg (lit.)

density

1.283 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Nc1ccc(cc1)C(F)(F)F

InChI

1S/C7H6F3N/c8-7(9,10)5-1-3-6(11)4-2-5/h1-4H,11H2

InChI key

ODGIMMLDVSWADK-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Leflunomide impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

1357045

1357056

1357067

PHR1378

Leflunomide, Pharmaceutical Secondary Standard; Certified Reference Material

BP1233

Leflunomide, British Pharmacopoeia (BP) Reference Standard

PHR2878

pictograms

GHS05,GHS06,GHS09

signalword

Danger

hcodes

H301 - H318 - H410

pcodes

P264 - P270 - P273 - P280 - P301 + P310 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

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Ribosomal proteins S3a, S13, S16, and S24 are not mutated in patients with Diamond-Blackfan anemia.

R Cmejla et al.

Blood, 97(2), 579-580 (2001-02-24)

Identification of genes encoding ribosomal protein L33 from Bacillus licheniformis, Thermus thermophilus and Thermotoga maritima.

P M Sharp

Gene, 139(1), 135-136 (1994-02-11)

Three previously unrecognized genes from Bacillus licheniformis, Thermus thermophilus and Thermotoga maritima, encoding ribosomal protein L33, have been identified and designated as rpmG genes. Their sequence and context have been compared with the three known rpmG genes from Escherichia coli

Effects of trifluoromethylaniline isomers on enzyme activities in lymphatic organs and hematology of the rat.

L Sebestová et al.

Toxicology, 92(1-3), 27-38 (1994-09-06)

Three isomers of trifluoromethylaniline (TFMA) were investigated for their possible different toxic effects on the hematopoietic system in male Wistar rats. The effects of isomeric 2-, 3- and 4-TFMA were compared with those of aniline, the prototypic drug. Strong leukocytosis

Synthesis of ribosomal proteins in developing Dictyostelium discoideum cells is controlled by the methylation of proteins S24 and S31.

Giorgio Mangiarotti

Biochemistry and cell biology = Biochimie et biologie cellulaire, 80(2), 261-270 (2002-05-07)

Ribosomal protein mRNAs left over from growth are selectively excluded from polyribosomes in the first half of Dictyostelium discoideum development. This is due to the fact that they are sequestered by a class of free 40S ribosomal subunits, characterized by

Ribosome assembly in three strains of Escherichia coli with mutations in the rpmB,G operon.

S H Coleman et al.

Journal of general microbiology, 139(4), 707-716 (1993-04-01)

The rpmB,G operon of Escherichia coli codes for the synthesis of ribosomal proteins L28 and L33. In one mutant strain (TP28), these two proteins are made at about half their normal rates, ribosome assembly is greatly perturbed and precursor particles

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