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Y0000816

Atropine impurity B

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Noratropine, N-Demethylatropine

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About This Item

Empirical Formula (Hill Notation):
C16H21NO3
CAS Number:
16839-98-8
Molecular Weight:
275.34
MDL number:
MFCD22666261
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

atropine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

O=C(C(CO)C1=CC=CC=C1)O[C@@H]2C[C@@H]3CC[C@@H](N3)C2

InChI

1S/C16H21NO3/c18-10-15(11-4-2-1-3-5-11)16(19)20-14-8-12-6-7-13(9-14)17-12/h1-5,12-15,17-18H,6-10H2

InChI key

ATKYNAZQGVYHIB-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Atropine impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Preparation of noratropine by oxidative n-demethylation of atropine.
M J Van der Meer et al.
The Journal of pharmacy and pharmacology, 35(6), 408-408 (1983-06-01)
Mohamad Houssam Al Balkhi et al.
Phytochemistry, 74, 105-114 (2011-11-16)
The presence of two compounds, norlittorine and norhyoscyamine, has been reported in leaves and roots of Datura innoxia; however their metabolic origin in the tropane alkaloid pathway has remained unknown. Precise knowledge of this pathway is a necessary pre-requisite to
M J Van der Meer et al.
The Journal of pharmacy and pharmacology, 38(10), 781-784 (1986-10-01)
A metabolic pattern of atropine in man, based on the detection of radiolabelled products in urine by high performance liquid chromatography after administration of [3H]atropine sulphate to a normal volunteer is proposed. Noratropine (24%), atropine-N-oxide (equatorial isomer) (15%), tropine (2%)

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