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Y0001518

Haloperidol for peak identification

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Haloperidol, 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone, 4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4′-fluorobutyrophenone, 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4′-fluorobutyrophenone

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About This Item

Empirical Formula (Hill Notation):
C21H23ClFNO2
CAS Number:
52-86-8
Molecular Weight:
375.86
MDL number:
MFCD00051423
UNSPSC Code:
41116107
PubChem Substance ID:
329831469
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

haloperidol

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3ccc(Cl)cc3

InChI

1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2

InChI key

LNEPOXFFQSENCJ-UHFFFAOYSA-N

Gene Information

human ... HTR2A(3356)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Haloperidol for peak identification EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

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Description
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H0100000

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Haloperidol, United States Pharmacopeia (USP) Reference Standard

H0100100

Haloperidol decanoate, European Pharmacopoeia (EP) Reference Standard

Y0001517

Haloperidol for system suitability, European Pharmacopoeia (EP) Reference Standard

1303013

Haloperidol Related Compound A, United States Pharmacopeia (USP) Reference Standard

1303057

Haloperidol decanoate, United States Pharmacopeia (USP) Reference Standard

1303024

Haloperidol Related Compound B, United States Pharmacopeia (USP) Reference Standard

PHR1724

Haloperidol, Pharmaceutical Secondary Standard; Certified Reference Material

BP407

Haloperidol, British Pharmacopoeia (BP) Reference Standard

PHR8951

Haloperidol Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Mark C Fok et al.
International journal of geriatric psychiatry, 30(4), 333-344 (2015-02-03)
To summarize the effect of antipsychotics for preventing postoperative delirium. We conducted a literature search using Medline, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews and clinicaltrials.gov. We included randomized controlled trials of adults undergoing surgery
Robin Nguyen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(45), 14948-14960 (2014-11-08)
Hyperactivity within the ventral hippocampus (vHPC) has been linked to both psychosis in humans and behavioral deficits in animal models of schizophrenia. A local decrease in GABA-mediated inhibition, particularly involving parvalbumin (PV)-expressing GABA neurons, has been proposed as a key
Marianne Klemp et al.
Journal of clinical psychopharmacology, 31(6), 698-704 (2011-10-25)
The objective of the study was to examine the efficacy and the degree of adverse effects connected with atypical neuroleptic drugs and haloperidol by using a previously described Bayesian statistical method that includes both direct and indirect comparisons simultaneously. The
Gil M Lewitus et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(18), 6146-6155 (2014-05-03)
Elevation of inflammatory cytokines in the striatum precedes symptoms in a number of motor dysfunctions, but it is unclear whether this is part of the disease process or an adaptive response to the pathology. In pyramidal cells, TNFα drives the
Lorna Donnelly et al.
The Cochrane database of systematic reviews, 8(8), CD001951-CD001951 (2013-08-29)
Haloperidol is a benchmark, accessible antipsychotic drug against which the effects of newer treatments are gauged. To determine the best range of doses for haloperidol for the treatment of people acutely ill with schizophrenia. We searched the Cochrane Schizophrenia Group
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