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27227

Sigma-Aldrich

Ethyl acetate

puriss., meets analytical specification of Ph. Eur., BP, NF, ≥99.5% (GC)

Synonym(s):

EtOAc

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About This Item

Linear Formula:
CH3COOC2H5
CAS Number:
Molecular Weight:
88.11
Beilstein/REAXYS Number:
506104
EC Number:
MDL number:
UNSPSC Code:
12352108
PubChem Substance ID:
NACRES:
NB.11

vapor density

3 (20 °C, vs air)

Quality Level

vapor pressure

73 mmHg ( 20 °C)

grade

puriss.

assay

≥99.5% (GC)

form

liquid

autoignition temp.

801 °F

quality

meets analytical specification of Ph. Eur., BP, NF

expl. lim.

2.2-11.5 %, 38 °F

impurities

residual solvents, complies
≤0.003% non-volatile matter
≤0.005% free acid (as CH3COOH)
≤0.01% methyl. comp.(as acetic acid methylester)
≤0.1% ethanol (GC)
≤0.1% water (Karl Fischer)
≤0.2% related subst. (GC)

refractive index

n20/D 1.371-1.373
n20/D 1.3720 (lit.)

bp

76.5-77.5 °C (lit.)

mp

−84 °C (lit.)

density

0.898-0.902 g/mL at 20 °C
0.894-0.898 g/mL at 25 °C
0.902 g/mL at 25 °C (lit.)

suitability

complies for appearance of solution
complies for reaction against H2SO4
corresponds for chromatography
passes test for identity (IR)

format

neat

SMILES string

CCOC(C)=O

InChI

1S/C4H8O2/c1-3-6-4(2)5/h3H2,1-2H3

InChI key

XEKOWRVHYACXOJ-UHFFFAOYSA-N

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Application


  • [Determination of 12 prohibited veterinary drug residues in pig urine by ultra high performance liquid chromatography-tandem mass spectrometry]: Ethyl acetate is utilized for sample preparation in this advanced method to detect drug residues in animal samples, emphasizing its role in veterinary pharmaceutical compliance (Wan et al., 2024).

  • Therapeutic effect of Ginkgetin on smoke-induced airway inflammation by down-regulating the c/EBPβ signaling pathway and CCL2 expression: This study explores the anti-inflammatory properties of Ginkgetin, where ethyl acetate is used in the extraction process, highlighting its utility in biomedical research (Tao et al., 2024).

  • Effect of methanol extract of Plectranthus esculentus N.E.Br tuber and its fractions on indices of benign prostatic hyperplasia in Wistar rats: Ethyl acetate is employed in the extraction of bioactive compounds for pharmacological studies, showing its critical role in therapeutic applications (Kanu et al., 2024).

  • Phytochemical evaluation of Ziziphus mucronata and Xysmalobium undulutum towards the discovery and development of anti-malarial drugs: Demonstrates the use of ethyl acetate in phytochemical screenings, contributing to the development of new anti-malarial medications (Buthelezi et al., 2024).

  • The First Records of the In Silico Antiviral and Antibacterial Actions of Molecules Detected in Extracts of Algerian Fir (Abies numidica De Lannoy) Using LC-MS/MS Analysis: This research utilizes ethyl acetate for extracting compounds from plants for antiviral and antibacterial testing, underscoring its importance in the study of natural products (Benouchenne et al., 2024).

Other Notes

The article number 27227-4X2.5L-M will be discontinued. Please order the single bottle 27227-2.5L-M which is physically identical with the same exact specifications.
The article number 27227-4X2.5L-R will be discontinued. Please order the single bottle 27227-2.5L-R which is physically identical with the same exact specifications.

pictograms

FlameExclamation mark

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system

supp_hazards

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

24.8 °F

flash_point_c

-4 °C


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Complete oxidation of CO, ethanol, and ethyl acetate over copper oxide supported on titania and ceria modified titania.
Larsson PO and Andersson A.
J. Catal., 179(1), 72-89 (1998)
K H Young et al.
Journal of clinical microbiology, 10(6), 852-853 (1979-12-01)
Ethyl acetate appears to be a satisfactory subsitute solvent for diethyl ether in the Formalin-ether sedimentation technique. In comparative studies, concentration of organisms with ethyl acetate was equal to or greater than that with diethyl ether. No distortion or alteration
K J S Anand et al.
British journal of anaesthesia, 101(5), 680-689 (2008-08-30)
Relationships between plasma morphine concentrations and neonatal responses to endotracheal tube (ETT) suctioning are unknown in preterm neonates. Ventilated preterm neonates (n=898) from 16 centres were randomly assigned to placebo (n=449) or morphine (n=449). After an i.v. loading dose (100
Jessica Le Ven et al.
Journal of mass spectrometry : JMS, 47(11), 1500-1509 (2012-11-14)
Annonaceous acetogenins (AAGs) are a homogenous class of polyketides proposed as environmental neurotoxins. Previous dereplication studies of AAGs were limited by the use of low-resolution mass spectrometers. Only poor information in terms of structures was provided due to the limited
Yuusuke Fujimoto et al.
PloS one, 7(11), e48685-e48685 (2012-11-13)
Combination therapy with ribavirin, interferon, and viral protease inhibitors could be expected to elicit a high level of sustained virologic response in patients infected with hepatitis C virus (HCV). However, several severe side effects of this combination therapy have been

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