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319988

Sigma-Aldrich

Chloroform

contains ethanol as stabilizer, ACS reagent, ≥99.8%

Synonym(s):

Methylidyne trichloride, Trichloromethane

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About This Item

Empirical Formula (Hill Notation):
CHCl3
CAS Number:
67-66-3
Molecular Weight:
119.38
Beilstein/REAXYS Number:
1731042
MDL number:
MFCD00000826
UNSPSC Code:
12191502
PubChem Substance ID:
329753942
NACRES:
NA.21

grade

ACS reagent

Quality Level

200

vapor density

4.1 (vs air)

vapor pressure

160 mmHg ( 20 °C)

assay

≥99.8%

form

liquid

contains

ethanol as stabilizer

impurities

Acetone and aldehyde, passes test
 Acid and chloride, passes test
 Free chlorine (Cl), passes test
 H2SO4, passes test

evapn. residue

≤0.001%

color

APHA: ≤10

refractive index

n20/D 1.445 (lit.)

bp

60.5-61.5 °C (lit.)

mp

−63 °C (lit.)

density

1.48 g/mL at 25 °C
1.492 g/mL at 25 °C (lit.)

cation traces

Pb: ≤0.05 ppm

storage temp.

room temp

SMILES string

ClC(Cl)Cl

InChI

1S/CHCl3/c2-1(3)4/h1H

InChI key

HEDRZPFGACZZDS-UHFFFAOYSA-N

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General description

Chloroform, a halogenated hydrocarbon, is widely used as a solvent and extractant in various manufacturing and laboratory procedures. It can be produced by the chlorination of methane or lower-chlorinated methanes. Additionally, it is employed in the production of dichlorocarbenes, α-trichloromethyl carbinols, and trichlorolithiocarbenoids.

Application

Chloroform can be used as a solvent in the:
  • Enzyme-catalyzed ring-opening polymerization of ω-pentadecalactone to prepare polyesters.
  • Pd-catalyzed cross-coupling reaction of acid chlorides with arylboronic acids to synthesize diaryl Ketones.
  • Enantio- and diastereoselective nitro-Mannich reaction of α-aryl nitromethanes with amido sulfones to synthesize β-nitroamines.
  • Diels-Alder reaction to synthesize spiro-fused dihydropyans. The hydrogen bond (CH-O) formed between chloroform and carbonyl oxygen makes the carbonyl group a stronger heterodienophile, resulting in an increased reaction rate.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

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