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Sigma-Aldrich

Dichloromethane

ACS reagent, ≥99.5%, contains 40-150 ppm amylene as stabilizer

Synonym(s):

methylene chloride, Methylene chloride

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About This Item

Empirical Formula (Hill Notation):
CH2Cl2
CAS Number:
Molecular Weight:
84.93
Beilstein/REAXYS Number:
1730800
EC Number:
MDL number:
UNSPSC Code:
12352101
PubChem Substance ID:
NACRES:
NA.04

grade

ACS reagent

Quality Level

agency

suitable for EPA 1613

vapor density

2.9 (vs air)

vapor pressure

24.45 psi ( 55 °C)
6.83 psi ( 20 °C)

assay

≥99.5%

form

liquid

autoignition temp.

1223 °F

contains

40-150 ppm amylene as stabilizer

expl. lim.

22 %

impurities

Free halogens, passes test
≤0.0003 meq/g Titr. acid
≤0.02% water

evapn. residue

≤0.002%

color

APHA: ≤10
clear

refractive index

n20/D 1.424 (lit.)

bp

39.8-40 °C (lit.)

mp

−95 °C (lit.)

density

1.325 g/mL at 25 °C (lit.)

SMILES string

ClCCl

InChI

1S/CH2Cl2/c2-1-3/h1H2

InChI key

YMWUJEATGCHHMB-UHFFFAOYSA-N

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Application


  • Rapid and Comprehensive Analysis of 41 Harmful Substances in Multi-Matrix Products by Gas Chromatography-Mass Spectrometry Using Matrix-Matching Calibration Strategy.: This research uses gas chromatography-mass spectrometry (GC-MS) to analyze harmful substances across various matrices. Dichloromethane is employed as a solvent in the preparation phase, highlighting its application in ensuring accurate and efficient analytical results (Wang Y et al., 2024).

  • Brunonianines D-F, three new C19-diterpenoid alkaloids from the Delphinium brunonianum, with therapeutic effect on ovarian cancer in vitro and in vivo.: This study identifies new alkaloids with potential anti-cancer properties, where dichloromethane is utilized in the extraction and isolation processes. Its effectiveness in separating and preserving delicate compounds is critical for their pharmacological evaluation (Li Q et al., 2024).

  • LC-HRMS and GC-MS Profiling of Urine Free Cortisol, Cortisone, 6Β-, and 18-Hydroxycortisol for the Evaluation of Glucocorticoid and Mineralocorticoid Disorders.: Utilizes LC-HRMS and GC-MS to profile hormones in urine, with dichloromethane being crucial in the extraction process. This method ensures precision and sensitivity in hormone measurement, essential for diagnosing endocrine disorders (Casals G et al., 2024).

  • Determination of vancomycin and meropenem in serum and synovial fluid of patients with prosthetic joint infections using UPLC-MS/MS.: Features a method to measure antibiotics in biological fluids, where dichloromethane is used to prepare samples. This study underscores the solvent′s role in achieving high resolution and detection limits in clinical diagnostics (He J et al., 2024).

Features and Benefits

ACS solvents meet or exceed the high standards of the American Chemical Society (ACS) ,with test specifications that are specialized to every compound. According to the American Chemical Society, ACS reagent grade implies that it is a substance of sufficient purity to be used in most chemical analyses or reactions.

pictograms

Health hazardExclamation mark

signalword

Warning

Hazard Classifications

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Central nervous system

wgk_germany

WGK 2

flash_point_f

does not flash

flash_point_c

does not flash


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Journal of Photochemistry and Photobiology A: Chemistry, 103(1), 153-157 (1997)
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