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383120

Sigma-Aldrich

Sulfamic acid

ACS reagent, 99.3%

Synonym(s):

Amidosulfonic acid

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About This Item

Linear Formula:
NH2SO3H
CAS Number:
5329-14-6
Molecular Weight:
97.09
EC Number:
226-218-8
MDL number:
MFCD00011603
UNSPSC Code:
12352106
PubChem Substance ID:
329755668
NACRES:
NA.21

grade

ACS reagent

Quality Level

200

assay

99.3%
99.3-100.3% dry basis (ACS specification)

form

crystals

technique(s)

titration: suitable

impurities

≤0.01% insolubles

ign. residue

≤0.01%

mp

215-225 °C (dec.) (lit.)

solubility

water: 213 g/L at 20 °C

density

2.151 g/cm3 at 25 °C

anion traces

chloride (Cl-): ≤0.001%
sulfate (SO42-): ≤0.05%

cation traces

Fe: ≤5 ppm
heavy metals (as Pb): ≤0.001%

SMILES string

NS(O)(=O)=O

InChI

1S/H3NO3S/c1-5(2,3)4/h(H3,1,2,3,4)

InChI key

IIACRCGMVDHOTQ-UHFFFAOYSA-N

Gene Information

human ... CA1(759) , CA2(760)

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General description

Sulfamic acid (H2NSO3H) is widely used inorganic compound. It exists in zwitterionic form and neutral forms. Zwitterionic form has been reported to be is more stable than neutral form. Its industrial applications have been reported. It has various organic synthesis applications.
Sulfamic acid is a strong inorganic acid. It is a hypochlorite scavenger. The ability of sulfamic acid to reduce nitrate to nitrogen gas under acidic condition has been utilized to denitrify nitrate-rich wastewater along with zinc powder.

Application

Sulfamic acid (H2NSO3H) may be used in the following studies:
  • As catalyst in the synthesis of aryl-14H-dibenzo[a.j]xanthenes.
  • As green catalyst for the preparation of amide from ketoxime.
  • As ammonia equivalent in the regioselective synthesis of primary allylic amines, via allylic substitution reactions.
  • Synthesis of polysubstituted quinolones.
Sulfamic acid may be used in the following processes:
  • As a titrant in the determination of the burette injection volume and chemical calibration factor.
  • To neutralize excess nitrous acid in the colorimetric paracetamol assay by modified Glynn and Kendal colorimetric method.
  • To prevent endogenous mercury (Hg) loss during the urine Hg measurement by inductively coupled plasma mass spectrometry (ICP-MS) method.
  • As an acid catalyst and a hypochlorite scavenger in the chlorite oxidation of dialdehyde cellulose (DAC).
  • As a heterogeneous catalyst in the synthesis of polyhydroquinoline derivatives by Hantzsch condensation reaction.
  • As catalyst in the degradation of bamboo fiber to 5-hydroxymethylfurfural (HMF).
  • As an acid reagent in the determination of silicates in water samples based on centrifugal microfluidics.
  • As catalyst in the synthesis of deazaoxaflavin at room temperature.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Aquatic Chronic 3 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

8B - Non-combustible, corrosive hazardous materials

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sulphamic acid assisted synthesis of polyhydroquinolines via Hantzsch multicomponent reaction: A green approach.
Lambat T, et al.
Journal of Chemical and Pharmaceutical Research, 6(4), 888-892 (2014)
Fathima Shihana et al.
Clinical toxicology (Philadelphia, Pa.), 48(1), 42-46 (2010-01-26)
Despite a significant increase in the number of patients with paracetamol poisoning in the developing world, plasma paracetamol assays are not widely available. The purpose of this study was to assess a low-cost modified colorimetric paracetamol assay that has the
Hyundoo Hwang et al.
Analytical chemistry, 85(5), 2954-2960 (2013-01-17)
In this study, we describe a novel platform based on centrifugal microfluidics for simultaneous determination of nitrite, nitrate and nitrite, ammonium, orthophosphate, and silicate in water samples. All processes from sample metering to detection were integrated and automatically conducted on
Anna Z Pollack et al.
Reproductive toxicology (Elmsford, N.Y.), 42, 41-48 (2013-07-31)
There has been limited study of trace elements and endometriosis. Using a matched cohort design, 473 women aged 18-44 years were recruited into an operative cohort, along with 131 similarly aged women recruited into a population cohort. Endometriosis was defined
Sulfamic Acid: Efficient, Cost-Effective Catalyst for Facile Synthesis of Deazaoxaflavin at Ambient Temperature.
Mane MM and Pore DM.
Synthetic Communications, 45(7), 868-876 (2015)
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