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A6283

Sigma-Aldrich

Acetic acid

glacial, ReagentPlus®, ≥99%

Synonym(s):

Glacial acetic acid

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About This Item

Linear Formula:
CH3CO2H
CAS Number:
64-19-7
Molecular Weight:
60.05
Beilstein/REAXYS Number:
506007
EC Number:
200-580-7
MDL number:
MFCD00036152
UNSPSC Code:
12352106
PubChem Substance ID:
329770889
NACRES:
NA.21

vapor density

2.07 (vs air)

Quality Level

200

product line

ReagentPlus®

assay

≥99%

form

liquid

autoignition temp.

800 °F

expl. lim.

16 %, 92 °F
4 %, 59 °F

refractive index

n20/D 1.371 (lit.)

pH

2.5 (20 °C, 50 g/L)

bp

117-118 °C (lit.)

mp

16.2 °C (lit.)

solubility

alcohol: miscible(lit.)
carbon disulfide: insoluble(lit.)
glycerol: miscible(lit.)
water: miscible(lit.)

density

1.049 g/mL at 25 °C (lit.)

storage temp.

room temp

SMILES string

CC(O)=O

InChI

1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)

InChI key

QTBSBXVTEAMEQO-UHFFFAOYSA-N

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General description

Acetic acid is an aliphatic organic acid. It is a hygroscopic, corrosive liquid with a vinegar-like odor. It can be synthesized by oxidizing acetaldehyde in the presence of manganese or cobalt salts. It is utilized for synthesizing acetic anhydride, cellulose acetate and acetic esters. Its impact on the degradation of historic paper has been analyzed.

Application

Acetic acid (AcOH) can be used as:      
  • A reaction solvent in many organic reactions such as bromination, hydrolysis, solvolysis, reductions, and hydrogenations.      
  • A reagent in the protonolysis of organometallic compounds.
  • An acetylating agent for the acetylation of electron-rich aromatic compounds.      
  • A catalyst to synthesize di(indolyl)methanes by the condensation reaction of indole and aromatic aldehydes.      
  • A solvent system to prepare 3,4-dihydropyrimidin-2(1H)-one derivative via Biginelli reaction of aromatic aldehydes, 1,3-dicarbonyl compounds, and urea in the presence of a boric acid catalyst.

Acetic acid can also be used in the following:     
  • Manganese(III) acetate/AcOH catalytic system is used in the conversion of alkenes to lactones.      
  • Iron salts/AcOH is used to oxidize 2-methylnaphthalene to 2-methyl-1-naphthol in the presence of H2O2.

Features and Benefits

  • Good stability towards many reagents     
  • Excellent solubility of organic compounds in this reagent

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ash M and Ash I.
Handbook of Preservatives, 266-266 (2004)
Effects of NO2 and acetic acid on the stability of historic paper.
Menart Eet al.
Cellulose, 21(5), 3701-3713 (2014)
Maize Kernels-Fixation in FAA, Embedding, Sectioning and Feulgen Staining.
Kladnik A.
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