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135R-1

Sigma-Aldrich

CD35 (EP197) Rabbit Monoclonal Primary Antibody

Synonym(s):

C3-binding protein, C3BR, C3b/C4b receptor, C4BR, CD35 antigen, CR1, Complement Receptor 1, Complement component (3b/4b) receptor 1 (Knops blood group), Knops blood group antigen

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP197, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (135R-14)
vial of 0.1 mL concentrate Research Use Only (135R-14-RUO)
vial of 0.5 mL concentrate (135R-15)
vial of 1.0 mL concentrate (135R-16)
vial of 1.0 mL concentrate Research Use Only (135R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (135R-17-RUO)
vial of 1.0 mL predilute ready-to-use (135R-17)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (135R-18-RUO)
vial of 7.0 mL predilute ready-to-use (135R-18)

manufacturer/tradename

Cell Marque™

concentration

0.1-5.0 μg/mL (predilute)
2.5-125 μg/mL (concentrate)

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

membranous

Gene Information

human ... CR1(1378)

Related Categories

General description

CD35 (complement receptor 1) is a cell membrane-bound, monomeric glycoprotein found on numerous cell types including erythrocytes, leukocytes, glomerular podocytes, and follicular dendritic cells. The primary function of CD35 is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles. CD35 antigen is found on erythrocytes, B cells, a subset of T cells, monocytes, as well as eosinophils and neutrophils. Anti-CD35 is considered a mature B-cell marker which labels follicular dendritic reticulum cells and tumors derived from such cells such as follicular dendritic cell tumor/sarcoma.

Quality

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

Linkage

CD35 Positive Control Slides, Product No. 135S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Inflammatory pseudotumor-like follicular dendritic cell tumor: a distinctive low-grade malignant intra-abdominal neoplasm with consistent Epstein-Barr virus association.
Cheuk W, Chan JK, Shek TW, et al.
American Journal of Surgical Pathology, 25(6), 721-731 (2001)
Mediastinal mixed dendritic cell sarcoma with hybrid features.
Dillon KM, Hill CM, Cameron CH, et al.
Journal of Clinical Pathology, 55(10), 791-794 (2002)
Germinal centre-like versus undifferentiated stromal immunophenotypes in follicular lymphoma.
Chang KC, Huang X, Medeiros LJ, et al.
The Journal of Pathology, 201(3), 404-412 (2003)
Extranodal follicular dendritic cell sarcoma of the head and neck region: three new cases, with a review of the literature.
Biddle DA, Ro JY, Yoon GS, et al.
Modern Pathology, 15(1), 50-58 (2002)
Immunohistochemical recognition of human follicular dendritic cell (FDCs) in routinely processed paraffin section.
Kunihikom, M., et al.
The Journal of Histochemistry and Cytochemistry, 50, 1475-1486 (2002)
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