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Sigma-Aldrich

Hydroxystilbamidine bis(methanesulfonate)

suitable for fluorescence, ≥96.0% (HPLC)

Synonym(s):

2-Hydroxystilbene-4,4′-dicarboxamidine bis(methanesulfonate), Fluoro-Gold

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About This Item

Empirical Formula (Hill Notation):
C18H24N4O7S2
CAS Number:
223769-64-0
Molecular Weight:
472.54
MDL number:
MFCD01863083
UNSPSC Code:
41116100
PubChem Substance ID:
57649893
NACRES:
NA.32

Quality Level

100

assay

≥96.0% (HPLC)

form

powder

fluorescence

λex 318 nm; λem 560 nm in TBE Buffer

suitability

suitable for fluorescence

storage temp.

2-8°C

SMILES string

CS(O)(=O)=O.CS(O)(=O)=O.NC(=N)c1ccc(cc1)\C=C\c2ccc(cc2O)C(N)=N

InChI

1S/C16H16N4O.2CH4O3S/c17-15(18)12-5-2-10(3-6-12)1-4-11-7-8-13(16(19)20)9-14(11)21;2*1-5(2,3)4/h1-9,21H,(H3,17,18)(H3,19,20);2*1H3,(H,2,3,4)/b4-1+;;

InChI key

YGNSQKCULHSJDC-HFPMQDOPSA-N

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General description

Hydroxystilbamidine bis (methanesulfonate), also known as Fluoro-Gold, is a retrograde fluorescent tracer. Chemically, Hydroxystilbamidine is a weak base and can cross cell membranes in its uncharged form.

A few properties of Hydroxystilbamidine bis (methanesulfonate) are:

  • Intense Fluorescence.
  • Extensive filling of dendrites.
  • High Resistance to fading.
  • No uptake by undamaged fibers.
  • No diffusion from labelled cells.
  • Highly compatible with other neuro-histochemical techniques.

Application

Hydroxystilbamidine bis(methanesulfonate), a fluorescent retrograde tracer (axonal transport), is used for neural mapping in microanatomical research.
Hydroxystilbamidine bis (methanesulfonate) or Fluoro-Gold (FG) is used to label neurons and investigate the early effects of hearing loss. It is used to study morphological features of extensive axonal projections within the CNS by labelling the cells.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lijie Chen et al.
Experimental and therapeutic medicine, 4(5), 844-848 (2012-12-12)
Understanding the microanatomy of the facial nerve is vital to functional restoration of facial nerve injury. This study aimed to locate the spatial orientation of five branches in the extratemporal trunk of the rat facial nerve (ETFN). Fifteen adult Sprague-Dawley
L C Schmued et al.
Brain research, 377(1), 147-154 (1986-07-02)
A new fluorescent dye, Fluoro-Gold, has been demonstrated to undergo retrograde axonal transport. Its properties include intense fluorescence, extensive filling of dendrites, high resistance to fading, no uptake by intact undamaged fibers of passage, no diffusion from labeled cells, consistent
Miyako Hatano et al.
Hearing research, 287(1-2), 57-66 (2012-06-26)
The purpose of this study was to investigate the effects of early hearing loss on the anatomy of the central auditory system, specifically, the ascending projections to the inferior colliculus (IC). We compared normal animals with animals deafened during early
N Kuwabara
Biotechnic & histochemistry : official publication of the Biological Stain Commission, 87(6), 413-422 (2012-06-21)
A method is described for studying the morphological features of extensive axonal projections within the central nervous system of the gerbil, Meriones anguiculatus. Potentially long descending axonal projections between the auditory thalamus and lower brainstem were used as a model.
Tímea Bácskai et al.
Brain structure & function, 219(1), 303-321 (2013-01-05)
We have mapped the motor neurons (MNs) supplying the major hindlimb muscles of transgenic (C57/BL6J-ChAT-EGFP) and wild-type (C57/BL6J) mice. The fluorescent retrograde tracer Fluoro-Gold was injected into 19 hindlimb muscles. Consecutive transverse spinal cord sections were harvested, the MNs counted
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