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482R-1

Sigma-Aldrich

p63 (EP174) Rabbit Monoclonal Primary Antibody

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP174

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (482R-14)
vial of 0.1 mL concentrate, Research Use Only (482R-14-RUO)
vial of 0.5 mL concentrate (482R-15)
vial of 1.0 mL concentrate (482R-16)
vial of 1.0 mL concentrate, Research Use Only (482R-16-RUO)
vial of 1.0 mL pre-dilute ready-to-use, Research Use Only (482R-17-RUO)
vial of 1.0 mL pre-dilute, ready to use (482R-17)
vial of 25.0 mL pre-dilute ready-to-use (482R-10)
vial of 25.0 mL pre-dilute ready-to-use, Research Use Only (482R-10-RUO)
vial of 7.0 mL pre-dilute, ready to use (482R-18)
vial of 7.0 mL pre-dilute, ready to use, Research Use Only (482R-18-RUO)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable (1:100-1:200 (concentrated))

isotype

IgG

control

lung (squamous cell carcinoma), prostate

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

General description

p63 is a transcription factor that regulates many cell activities, including cell proliferation, maintenance, differentiation, adhesion, and apoptosis.1 It has been found to be a sensitive and specific marker of myoepithelial and basal cell populations in prostate, breast, skin, and salivary gland. Additionally, p63 has also demonstrated immunohistochemical utility in identifying benign and malignant breast lesions.2 In prostatic carcinomas, it can also be used to recognize benign glands adjacent to malignant glands.3 p63 can also be used to differentiate adenocarcinoma of the lungs, where it is usually negative, from squamous cell carcinoma, which can be useful for advanced stages of the carcinoma where surgery is no longer an option.4

Quality

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

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Certificates of Analysis (COA)

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A Yang et al.
Molecular cell, 2(3), 305-316 (1998-10-17)
We describe the cloning of p63, a gene at chromosome 3q27-29 that bears strong homology to the tumor suppressor p53 and to the related gene, p73. p63 was detected in a variety of human and mouse tissues, including proliferating basal

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