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69579

Sigma-Aldrich

γ,γ-Dimethylallyl pyrophosphate ammonium salt

≥93.0% (TLC)

Synonym(s):

3-Methyl-2-butenyl pyrophosphate ammonium salt, DMAPP, Prenyl pyrophosphate ammonium salt

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About This Item

Empirical Formula (Hill Notation):
C5H12O7P2 · xNH3
CAS Number:
69382-61-2
Molecular Weight:
246.09 (free acid basis)
UNSPSC Code:
12352205
NACRES:
NA.25

Quality Level

100

assay

≥93.0% (TLC)

form

powder

storage temp.

−20°C

SMILES string

N.C\C(C)=C\COP(O)(=O)OP(O)(O)=O

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Application

Prenyl pyrophosphate, an intermediate in mevalonic acid pathway isoprenoid/terpene biosynthesis, is use to study the kinetics of farnesyl pyrophosphate synthases.

Biochem/physiol Actions

Intermediate in terpene biosynthesis

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Farnesyl pyrophosphate synthase: a key enzyme in isoprenoid biosynthetic pathway and potential molecular target for drug development.
Dhar MK, Koul A, Kaul S.
New Biotechnology (2012)
Shuting Sun et al.
Expert opinion on therapeutic patents, 21(9), 1433-1451 (2011-06-28)
Farnesyl pyrophosphate synthase (FPPS, also known as farnesyl diphosphate synthase (FDPS)) is one of the key enzymes involved in the mevalonate pathway and as such is widely expressed. FPPS modulators, specifically FPPS inhibitors, are useful in treating a number of
Anuradha Srivastava et al.
Infectious disorders drug targets, 8(1), 16-30 (2008-05-14)
Synthesis of farnesyl pyrophosphate (FPP), a key intermediate of the isoprenoid biosynthesis pathway, is catalyzed by FPP synthase (FPPS). Antiprotozoal properties of bisphosphonates, which target FPPS, have generated interest in FPPS as a potential antiprotozoal drug target. The genes encoding

Articles

Analysis of Isoprenoid Pathway Metabolites by LC-MS

Read our Biofiles article on Analysis of Isoprenoid Pathway Metabolites by LC-MS.

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