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A6419

Sigma-Aldrich

Adenosine 5′-triphosphate disodium salt hydrate

microbial, BioReagent, suitable for cell culture, ≥99% (HPLC)

Synonym(s):

ATP disodium salt

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About This Item

Empirical Formula (Hill Notation):
C10H14N5Na2O13P3 · xH2O
CAS Number:
34369-07-8
Molecular Weight:
551.14 (anhydrous basis)
MDL number:
MFCD00150755
UNSPSC Code:
12352207
eCl@ss:
32160414
PubChem Substance ID:
24891086
NACRES:
NA.75

biological source

microbial

Quality Level

200

product line

BioReagent

assay

≥99% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

solubility

H2O: 50 mg/mL

storage temp.

−20°C

SMILES string

O.[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O

InChI

1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1

InChI key

NTBQNWBHIXNPRU-MSQVLRTGSA-L

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General description

Adenosine 5′-triphosphate (ATP) is essential for biological processes including neurotransmission, signal transduction, muscle contraction and cardiac function. ATP is the major energy potential for living systems. They are released from cells under stress and play a key role in immune response. ATP release from injured neurons and consequent breakdown leads to generation of adenosine. ATP may serve as a therapeutic option in anaesthesia and intensive care medicine for the management of pain. Elevated ATP levels are indicative of cell damage and inflammation.

Application

Adenosine 5′-triphosphate disodium salt hydrate has been used:
  • as a component of transfection mix for the transformation of CRISPR/Cas9 plasmid in parasites
  • in inflammasome activation assays in bone marrow derived macrophages
  • for the stimulation of macrophages
  • in nucleotide synthesis

Biochem/physiol Actions

P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Potential value of adenosine 5?-triphosphate (ATP) and adenosine in anaesthesia and intensive care medicine
Skrabanja ATP, et al.
British Journal of Anaesthesia, 94(5), 556-562 (2005)
Effect of interleukin-31 on septic shock through regulating inflammasomes and interleukin-1beta
Gu X, et al.
Experimental and Therapeutic Medicine, 16(1), 171-177 (2018)
Deuterated nucleotides as chemical probes of RNA structure: a detailed protocol for the enzymatic synthesis of a complete set of nucleotides specifically deuterated at ribose carbons
Tullius T, et al.
ScienceOpen Research (2018)
Adenosine and its receptors as therapeutic targets: an overview
Sachdeva S and Gupta M
Saudi Pharmaceutical Journal : SPJ : The Official Publication of the Saudi Pharmaceutical Society, 21(3), 245-253 (2013)
Pharmacology of adenosine receptors and their signaling role in immunity and inflammation
Pharmacology & Therapeutics, 21(3), 245-253 (2014)
View All Related Papers

Protocols

HPLC Analysis of Adenosine Nucleosides on Supelcosil™ LC-18-T

Separation of Adenosine 5′-triphosphate disodium salt hydrate, BioXtra, ≥99% (HPLC), from microbial; Adenosine 5′-diphosphate sodium salt, bacterial, ≥95% (HPLC); 2′-Deoxyadenosine 5′-monophosphate, Sigma Grade, 98-100%

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