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A7075

Sigma-Aldrich

Adrenocorticotropic Hormone rat

≥95% (HPLC)

Synonym(s):

Adrenocorticotropic hormone fragment 1-39, Corticotropin A

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About This Item

Empirical Formula (Hill Notation):
C210H315N57O57S
CAS Number:
77465-10-2
Molecular Weight:
4582.16
MDL number:
MFCD00167431
UNSPSC Code:
51111800
NACRES:
NA.32

sterility

non-sterile

Quality Level

200

assay

≥95% (HPLC)

form

powder

solubility

1% acetic acid: 1.00-1.04 mg/mL, clear, colorless
water: 1.00-1.04 mg/mL, clear, colorless

UniProt accession no.

P01194

shipped in

ambient

storage temp.

−20°C

Gene Information

rat ... Pomc(24664)

Related Categories

Amino Acid Sequence

Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Val-Ala-Glu-Asn-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe

Biochem/physiol Actions

Stimulates synthesis and secretion of glucocorticoids by adrenal cortex.

Other Notes

Lyophilized from 0.1% TFA in H2O

pictograms

Exclamation markHealth hazard
GHS07,GHS08

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hasan Arrat et al.
PloS one, 10(5), e0125638-e0125638 (2015-05-09)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a complex etiology and pathology that makes the development of new therapies difficult. ACTH has neurotrophic and myotrophic effects, but has not been tested in an ALS mouse model. The G93A-SOD1
Carla Schulz et al.
American journal of physiology. Endocrinology and metabolism, 298(2), E237-E244 (2009-11-19)
ACTH and alpha-melanocyte-stimulating hormone (alpha-MSH) are both consecutively processed from proopiomelanocortin (POMC), which is synthesized in hypothalamic arcuate neurons innervating the paraventricular nuclei (PVN). POMC secretion/synthesis is regulated by energy availability. ACTH and alpha-MSH bind with equal affinity to melanocortin-4

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