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A7785

Sigma-Aldrich

Apolipoprotein C-I from human plasma

≥95% (SDS-PAGE), lyophilized powder

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About This Item

CAS Number:
2235444-72-9
MDL number:
MFCD00162928
UNSPSC Code:
12352202
NACRES:
NA.77

biological source

human

Quality Level

200

assay

≥95% (SDS-PAGE)

form

lyophilized powder

mol wt

average mol wt 6.6 kDa

technique(s)

inhibition assay: suitable

UniProt accession no.

P02654

storage temp.

−20°C

Gene Information

human ... APOC1(341)

General description

Very low density lipoprotein.

Application

Apolipoprotein C-1 directly interferes with fatty acid uptake and is a major plasma inhibitor of cholesterol ester transfer protein. Apolipoprotein C-I has been used to develop a quantitative strategy, named secretome-derived isotopic tag (SDIT), to concurrently identify and quantify the adipocyte-secreted plasma proteins from normal and high-fat-diet (HFD) induced obese mice.

Biochem/physiol Actions

Interferes directly with fatty acid uptake and is the major plasma inhibitor of cholesterol ester transfer protein.

Physical form

Lyophilized from 10 mM NH4HCO3, pH 7.5

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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B S Suri et al.
The Biochemical journal, 178(2), 455-466 (1979-02-15)
1. The work reported was designed to provide quantitative information about the capacity of the extrahepatic tissues of the rat to degrade injected VLD lipoproteins (very-low-density lipoproteins, d less than 1.006) to LD lipoproteins (low-density lipoproteins, d 1.006--1.063) and to
Rong-Xia Li et al.
Journal of proteome research, 11(5), 2851-2862 (2012-03-13)
We developed a quantitative strategy, named secretome-derived isotopic tag (SDIT), to concurrently identify and quantify the adipocyte-secreted plasma proteins from normal and high-fat-diet (HFD) induced obese mice, based on the application of isotope-labeled secreted proteins from cultured mouse adipocytes as
Nathan L Meyers et al.
Biochemistry, 51(6), 1238-1248 (2012-01-24)
Apolipoprotein C-I (apoC-I) is an important constituent of high-density lipoprotein (HDL) and is involved in the accumulation of cholesterol ester in nascent HDL via inhibition of cholesterol ester transfer protein and potential activation of lecithin:cholesterol acyltransferase (LCAT). As the smallest

Articles

Cholesterol Transport

Since cholesterol is a water-insoluble molecule it must be packaged for transport within the plasma. The particles that package cholesterol, cholesteryl esters, and triglycerides for transport, are called lipoproteins.

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