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A9736

Sigma-Aldrich

A-438079 hydrochloride hydrate

≥98% (HPLC)

Synonym(s):

3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methyl pyridine hydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):
C13H9Cl2N5·HCl · xH2O
CAS Number:
899431-18-6
Molecular Weight:
342.61 (anhydrous basis)
MDL number:
MFCD17215929
UNSPSC Code:
12352200
PubChem Substance ID:
329771058
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 20 mg/mL, clear

originator

Abbott

storage temp.

2-8°C

SMILES string

O.Cl.Clc1cccc(c1Cl)-c2nnnn2Cc3cccnc3

InChI

1S/C13H9Cl2N5.ClH.H2O/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9;;/h1-7H,8H2;1H;1H2

InChI key

ZHFJJBAKSROKNO-UHFFFAOYSA-N

Application

A-438079 hydrochloride hydrate has been used to determine its inhibitory effect on purinergic receptors. It has also been used to check its inhibitory effects on macrophages.

Biochem/physiol Actions

A-438079 hydrochloride hydrate is a selective P2X7 purinoceptor antagonist in both human and rat with minimal activity at 75 different G-protein-coupled receptors, enzymes, transporters, and ion channels tested.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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