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A9791

Sigma-Aldrich

Asialoglycophorin from Human Blood Type MN

lyophilized powder

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About This Item

MDL number:
MFCD00130563
UNSPSC Code:
12352204
NACRES:
NA.54

biological source

human blood (type MN)

Quality Level

200

form

lyophilized powder

concentration

30.00-50.00% (Lowry)

storage temp.

−20°C

Related Categories

Application

Glycophorin is the major sialylated protein of the erythrocyte membrane. Product A9791 is asialoglycophorin from human blood type MN. Glycophorin has been inserted into target cells, by electropulsation, to study resistance to natural killer cells .

Biochem/physiol Actions

M and N active glycopeptides have identical amino acid sequences, except at residues 1 and 5, and glycosylated residues 2 to 4, which contain approximately 5 sialic acid groups. The removal of sialic acid from glycophorin destroys M and N activity. Glycophorin A may be involved in the resistance of target cells to natural killing.

Other Notes

Predominantly asialoglycophorin A

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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K el Ouagari et al.
The Journal of biological chemistry, 270(45), 26970-26975 (1995-11-10)
Glycophorin A is a protein with an abundant glycosylation (60% carbohydrate by weight), and studies have suggested that resistance of target cells to natural killing may be correlated with the level of glycophorin A expression. To assess the role of

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