AC-0362
ACTH (EP390) Rabbit Monoclonal Primary Antibody
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
antibody form
Ig fraction of antiserum
clone
monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
isotype
IgG
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic
General description
Adrenocorticotropic hormone (ACTH), also known as corticotropin, is produced from corticotropes in the anterior lobe of the pituitary gland. ACTH is released by corticotropin-releasing hormone stimulation by the hypothalamus in response to biological stress. Identifying ACTH is useful in the classification of pituitary tumors and diseases. Cushing′s disease derived from ACTH producing adenomas represents 10-15% of pituitary tumors. By immunohistochemistry (IHC), these tumors are immunoreactive for ACTH, beta-Lipotropin, and beta-endorphin. ACTH is also detected in a subset of growth hormone (GH), thyroid-stimulating hormone (TSH) and follicle-stimulating hormone (FSH) secreting adenomas. With the exception for ACTH secreting adenomas, most functioning adenomas are usually macroadenomas; tumors larger than 10 mm. A combination of ACTH IHC and reticulin staining also provides utility in the differential diagnosis between pituitary adenoma versus corticotroph hyperplasia. Breakdown of acinar structure and ACTH immunoreactivity are suggestive of adenoma.
Quality
 IVD |  IVD |  IVD |  RUO |
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Other Notes
For a copy of the IFU and CofA contact IVDorder@ABCAM.com
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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