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AV32030

Sigma-Aldrich

Anti-MyCN antibody produced in rabbit

IgG fraction of antiserum

Synonym(s):

Anti-v-Myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

50 kDa

species reactivity

dog, horse, bovine, mouse, human

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_005369

UniProt accession no.

P04198

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MYCN(4613)

General description

MyCN is a basic helix-loop-helix protein that has been implicated neuroblastomas. Studies have linked childhood neuroblastomas with MyCN amplifications to caspase 8 supression.
Rabbit Anti-MyCN antibody recognizes rat, canine, mouse, and human MyCN.

Immunogen

Synthetic peptide directed towards the C terminal region of human MYCN

Application

Rabbit Anti-MyCN antibody can be used for western blot applications at a concentration of 2.5μg/ml.

Biochem/physiol Actions

MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. It is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas

Sequence

Synthetic peptide located within the following region: EDAPPQKKIKSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILER

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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T Teitz et al.
Nature medicine, 6(5), 529-535 (2000-05-10)
Caspase 8 is a cysteine protease regulated in both a death-receptor-dependent and -independent manner during apoptosis. Here, we report that the gene for caspase 8 is frequently inactivated in neuroblastoma, a childhood tumor of the peripheral nervous system. The gene

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