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AV35734

Sigma-Aldrich

Anti-PIAS2 (AB1) antibody produced in rabbit

IgG fraction of antiserum

Synonym(s):

Anti-Protein inhibitor of activated STAT, 2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

68 kDa

species reactivity

bovine, human, dog, horse, rabbit

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_004662

UniProt accession no.

O75928

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PIAS2(9063)

Immunogen

Synthetic peptide directed towards the C terminal region of human PIAS2

Biochem/physiol Actions

Protein inhibitor of activated STAT (PIAS) family of proteins mediates the sumoylation of proteins by acting as SUMO E3 ligases. Some important proteins that are sumoylated by PIAS are p53, c-Jun and the androgen receptor.

Sequence

Synthetic peptide located within the following region: LTSPLTASSTSVTTTSSHESSTHVSSSSSRSETGVITSSGSNIPDIISLD

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Brendan Burn et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 240(9), 2120-2126 (2011-07-23)
Originally identified as cytokine inhibitors, protein inhibitors of activated STAT (PIAS) are shown to regulate activities of a plethora of proteins and influence diverse processes such as immune response, cancer formation, and cell cycle progression. However, the roles of PIAS
Jocelyn Widagdo et al.
PloS one, 7(11), e49283-e49283 (2012-11-13)
GTF2IRD1 is one of the genes implicated in Williams-Beuren syndrome, a disease caused by haploinsufficiency of certain dosage-sensitive genes within a hemizygous microdeletion of chromosome 7. GTF2IRD1 is a prime candidate for some of the major features of the disease

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