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AV36668

Sigma-Aldrich

Anti-MCM8 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-C20orf154, Anti-MGC119522, Anti-MGC119523, Anti-MGC12866, Anti-MGC4816, Anti-Minichromosome maintenance complex component 8, Anti-REC, Anti-dJ967N21.5

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

94 kDa

species reactivity

bovine, rabbit, human, guinea pig, horse, rat, mouse

concentration

0.5 mg - 1 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_115874

UniProt accession no.

Q9UJA3

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MCM8(84515)

Immunogen

Synthetic peptide directed towards the C terminal region of human MCM8

Biochem/physiol Actions

Minichromosome maintenance complex component 8 (MCM8) is one of the mini-chromosome maintenance proteins that are crucial for eukaryotic genome replication. MCM proteins are key components of the pre-replication complex, recruit replication-related proteins and form replication forks. MCM8 complexes with MCM9 to recruit RAD51 at the sites of DNA damage to facilitate homologous recombination.

Sequence

Synthetic peptide located within the following region: IRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQH

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The dimeric Mcm8-9 complex of Xenopus laevis likely has a conserved function for resistance to DNA damage.
Masato T Kanemaki
Cell cycle (Georgetown, Tex.), 12(9), 1338-1339 (2013-04-17)
Jonghoon Park et al.
Molecular and cellular biology, 33(8), 1632-1644 (2013-02-13)
The minichromosome maintenance protein homologs MCM8 and MCM9 have previously been implicated in DNA replication elongation and prereplication complex (pre-RC) formation, respectively. We found that MCM8 and MCM9 physically associate with each other and that MCM8 is required for the
Matthew L Bochman et al.
Microbiology and molecular biology reviews : MMBR, 73(4), 652-683 (2009-12-01)
The Mcm2-7 complex serves as the eukaryotic replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. Consistent with its central role in this process, much prior work has illustrated that Mcm2-7 loading

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