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AV43805

Sigma-Aldrich

Anti-SLC12A2 antibody produced in rabbit

IgG fraction of antiserum

Synonym(s):

Anti-BSC, Anti-BSC2, Anti-MGC104233, Anti-NKCC1, Anti-Solute carrier family 12 (sodium/potassium/chloride transporters), member 2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

131 kDa

species reactivity

rat, dog, rabbit, bovine, pig, horse, human, mouse

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_001037

UniProt accession no.

P55011

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SLC12A2(6558)

Immunogen

Synthetic peptide directed towards the C terminal region of human SLC12A2

Biochem/physiol Actions

SLC12A2 is sodium and chloride ion transporter that is activated in response to DNA damage. It regulates ionic balance in the cell and maintains the cell volume.

Sequence

Synthetic peptide located within the following region: IIAFEEIIEPYRLHEDDKEQDIADKMKEDEPWRITDNELELYKTKTYRQI

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Bo Ding et al.
American journal of physiology. Cell physiology, 306(1), C66-C75 (2013-11-01)
Sodium/potassium/chloride cotransporter (NKCC1) proteins play important roles in Na(+) and K(+) concentrations in key physiological systems, including cardiac, vascular, renal, nervous, and sensory systems. NKCC1 levels and functionality are altered in certain disease states, and tend to decline with age.

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